公开(公告)号：US20230312523A1

公开(公告)日：2023-10-05

申请号：US18010905

申请日：2021-06-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

CPC classification number: C07D403/10 ,  C07D403/14 ,  C09B23/0066

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near- infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The compounds have formula (I), formula (I), wherein X is direct bond or —O—; Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups; R1 and R2 are each independently a linear or branched C1-C6 alkyl substituted by a group selected from —SO3H, —COOH, —CONH2 and — COO—C1-C6 alkyl; and R3 is hydrogen, —SO3H or a linear or branched C1-C6 alkyl substituted by —COOH or —CONH—Y, wherein Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups.

公开(公告)号：US20230203129A1

公开(公告)日：2023-06-29

申请号：US17786669

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/71 ,  C07K1/13 ,  G01N33/533

CPC classification number: C07K14/71 ,  C07K1/13 ,  G01N33/533

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20230040008A1

公开(公告)日：2023-02-09

申请号：US17786768

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/00 ,  A61K49/00 ,  C07K1/13

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20240083880A1

公开(公告)日：2024-03-14

申请号：US18388604

申请日：2023-11-10

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

CPC classification number: C07D403/10 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/0075

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof.
The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.

公开(公告)号：US20250084066A1

公开(公告)日：2025-03-13

申请号：US18958122

申请日：2024-11-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20150158887A1

公开(公告)日：2015-06-11

申请号：US14623202

申请日：2015-02-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Federico MAISANO ,  Federico CRIVELLIN

IPC: C07F5/00

CPC classification number: C07F5/003 ,  C07C227/16 ,  C07C227/40 ,  C07C229/76

Abstract: The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way.

Abstract translation: 本发明通常依赖于制备螯合化合物的方法，其包括固体基质和螯合剂之间的选择性相互作用。 更详细地说，本发明能够以高产率和可靠的方式制备用作诊断剂的螯合化合物。