公开(公告)号：US20170340755A1

公开(公告)日：2017-11-30

申请号：US15535937

申请日：2015-12-18

Applicant: BRACCO IMAGING S.P.A.

Inventor： Alessandro MAIOCCHI ,  Chiara BRIOSCHI ,  Fulvio UGGERI ,  Giovanni VALBUSA

IPC: A61K49/00 ,  A61B10/00 ,  A61B5/08 ,  A61B5/00

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

公开(公告)号：US20220242853A1

公开(公告)日：2022-08-04

申请号：US17610779

申请日：2020-05-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Chiara BRIOSCHI ,  Federica BUONSANTI ,  Luigi MIRAGOLI ,  Roberta NAPOLITANO ,  Laura ORIO ,  Lorena PIZZUTO ,  Giovanni VALBUSA

IPC: C07D403/14 ,  C07D403/06 ,  C07D471/04 ,  C09B23/06 ,  C09B23/08 ,  A61K49/00

Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.