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公开(公告)号：US10995131B2
公开(公告)日：2021-05-04
申请号：US15826196
申请日：2017-11-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07K19/00 , C40B40/08 , C40B40/10 , C12N15/10 , C12N15/09 , A61K38/39 , C07H21/04 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
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公开(公告)号：US09328157B2
公开(公告)日：2016-05-03
申请号：US14071069
申请日：2013-11-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07H21/04 , C12N15/09 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30 , A61K38/39 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
Abstract translation: 本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。 本公开还提供了与单结构域结合多肽相关的各种改进。
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公开(公告)号：US09862758B2
公开(公告)日：2018-01-09
申请号：US15070572
申请日：2016-03-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07H21/04 , C12N15/09 , C07K19/00 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30 , A61K38/39 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
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