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公开(公告)号：US20210395200A1
公开(公告)日：2021-12-23
申请号：US17292123
申请日：2019-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Alina Borovika , Sergei Kolotuchin , Michael R. Luzung , Jeffrey A. Nye , Yichen Tan , Serge Zaretsky , Jason J. Zhu , Martin D. Eastgate
IPC: C07D207/273
Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.
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公开(公告)号：US12060384B2
公开(公告)日：2024-08-13
申请号：US17428548
申请日：2020-02-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Changxia Yuan , Michael Anthony Schmidt , Adrian Ortiz , Amanda J. Rogers , Jason J. Zhu , Zhongmin Xu , Miao Yu , Eric M. Simmons , Shulin Wu
IPC: C07H19/167 , C07H5/06
CPC classification number: C07H19/167 , C07H5/06
Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.
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Patent Agency Ranking
公开(公告)号：US10106560B2
公开(公告)日：2018-10-23
申请号：US15623570
申请日：2017-06-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Carlos A. Guerrero , Bin Zheng , Jason J. Zhu , Michael Anthony Schmidt , Michael R. Luzung , Martin D. Eastgate
IPC: C07D417/12 , C07F7/18 , C07D211/28 , C07F7/08
Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.
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公开(公告)号：US20230357306A1
公开(公告)日：2023-11-09
申请号：US17428548
申请日：2020-02-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Changxia Yuan , Michael Anthony Schmidt , Adrian Ortiz , Amanda J. Rogers , Jason J. Zhu , Zhongmin Xu , Miao Yu , Eric M. Simmons , Shulin Wu
IPC: C07H19/167 , C07H5/06
CPC classification number: C07H19/167 , C07H5/06
Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.
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公开(公告)号：US09249171B2
公开(公告)日：2016-02-02
申请号：US14402231
申请日：2013-05-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Tamas Benkovics , Zhongping Shi , Prashant P. Deshpande , Zhiwei Guo , David R. Kronenthal , Chris Sfouggatakis
IPC: C07H15/20 , C07H19/06 , C12P19/38 , C07D309/10 , C07D407/04 , C07D307/20
CPC classification number: C07H15/20 , C07D307/20 , C07D309/10 , C07D407/04 , C07H19/06 , C12P19/385
Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
Abstract translation: 制备式I化合物的方法利用起始化合物以及稍后的亚硫酰亚胺和亚砜工艺步骤。
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公开(公告)号：US20160130260A1
公开(公告)日：2016-05-12
申请号：US14896995
申请日：2014-06-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Tamas Benkovics , Martin D. Eastgate
IPC: C07D407/04
CPC classification number: C07D407/04 , C07C315/04 , C07C319/14 , C07C319/20 , C07C317/18 , C07C323/65
Abstract: Tert-butyl sulphoxide method for producing festinavir is set forth.
Abstract translation: 阐述了用于制备节食者的叔丁基亚砜方法。
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公开(公告)号：US20150140610A1
公开(公告)日：2015-05-21
申请号：US14402231
申请日：2013-05-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Tamas Benkovics , Zhongping Shi , Prashant P. Deshpande , Zhiwei Guo , David R. Kronenthal , Chris Sfouggatakis
CPC classification number: C07H15/20 , C07D307/20 , C07D309/10 , C07D407/04 , C07H19/06 , C12P19/385
Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
Abstract translation: 制备式I化合物的方法利用起始化合物以及稍后的亚硫酰亚胺和亚砜工艺步骤。
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