公开(公告)号：US20160376307A1

公开(公告)日：2016-12-29

申请号：US14903306

申请日：2014-07-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kyoung S. KIM ,  Liping ZHANG ,  Erik M. STANG

IPC: C07K5/083 ,  A61K38/06 ,  A61K45/06

CPC classification number: C07K5/0806 ,  A61K38/00 ,  A61K38/06 ,  A61K45/06 ,  C07K14/4747 ,  C07K14/8139

Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

公开(公告)号：US20160376288A1

公开(公告)日：2016-12-29

申请号：US15189388

申请日：2016-06-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Robert M. BORZILLERI ,  Andrew J. TEBBEN ,  Erik M. STANG ,  Andrew F. DONNELL ,  Gretchen M. SCHROEDER ,  Heidi L. PEREZ ,  Donna D. WEI

IPC: C07D498/22 ,  C07K16/30 ,  A61K47/48

CPC classification number: C07D498/22 ,  A61K31/5513 ,  A61K31/5517 ,  A61K47/48384 ,  A61K47/48569 ,  A61K47/48592 ,  A61K47/48615 ,  A61K47/48638 ,  A61K47/48715 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069

Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

Abstract translation: 并且式I，Ia和Ib中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是用作抗体 - 药物偶联物（ADC）中的药物成分时。