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公开(公告)号：US10369205B2
公开(公告)日：2019-08-06
申请号：US15108744
申请日：2015-01-07
申请人： Babita Agrawal , Rakesh Kumar
发明人： Babita Agrawal , Rakesh Kumar
IPC分类号： A61K39/02 , A61K39/39 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/35 , A61K39/395
摘要： The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
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公开(公告)号：US08227594B2
公开(公告)日：2012-07-24
申请号：US12467939
申请日：2009-05-18
IPC分类号： A61K31/7068 , A61K31/7072
CPC分类号： C07D239/54 , C07D403/04 , C07D491/04 , C07H19/06 , C07H19/23
摘要： Disclosed are nucleosides which are useful in diagnosing and treating viral infections, for example, infections caused by hepatitis B virus (HBV), and herpes viruses including Epstein Barr virus.
摘要翻译： 公开了可用于诊断和治疗病毒感染的核苷，例如由乙型肝炎病毒（HBV）引起的感染，以及包括爱泼斯坦巴尔病毒在内的疱疹病毒。
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公开(公告)号：US07589077B2
公开(公告)日：2009-09-15
申请号：US10477763
申请日：2002-05-17
IPC分类号： A61K31/7068 , A61K31/7072 , C07H19/06 , C07H19/067 , C07H19/073 , C07H19/09
CPC分类号： C07D239/54 , C07D403/04 , C07D491/04 , C07H19/06 , C07H19/23
摘要： Disclosed are nucleosides which are useful in diagnosing and treating viral infections, for example, infections caused by hepatitis B virus (HBV), and herpes viruses including Epstein Barr virus.
摘要翻译： 公开了可用于诊断和治疗病毒感染的核苷，例如由乙型肝炎病毒（HBV）引起的感染，以及包括爱泼斯坦巴尔病毒在内的疱疹病毒。
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公开(公告)号：US11419904B2
公开(公告)日：2022-08-23
申请号：US17372614
申请日：2021-07-12
申请人： Babita Agrawal , Rakesh Kumar , Nancy Gupta
发明人： Babita Agrawal , Rakesh Kumar , Nancy Gupta
摘要： The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.
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公开(公告)号：US20180000926A1
公开(公告)日：2018-01-04
申请号：US15543216
申请日：2016-01-15
申请人： Babita Agrawal , Rakesh Kumar , Shakti Singh
发明人： Babita Agrawal , Rakesh Kumar , Shakti Singh
CPC分类号： A61K39/12 , A61K39/0011 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/575 , C12N7/00 , C12N2710/10043 , C12N2770/24234 , C12N2770/24271
摘要： The present disclosure provides methods for inducing an immune response to hepatitis C virus (HCV) in an individual. The present disclosure provides methods for treating an HCV infection in an individual.
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公开(公告)号：US20160317637A1
公开(公告)日：2016-11-03
申请号：US15108744
申请日：2015-01-07
申请人： Babita Agrawal , Rakesh Kumar
发明人： Babita Agrawal , Rakesh Kumar
IPC分类号： A61K39/02 , A61K39/35 , A61K39/395 , A61K39/00
CPC分类号： A61K39/02 , A61K39/0011 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/35 , A61K39/39 , A61K39/395 , A61K2039/505 , A61K2039/521 , A61K2039/55516 , A61K2039/55572 , A61K2039/58 , C12N2710/10343 , C12N2730/10134 , C12N2760/16134 , C12N2760/16234 , C12N2770/24234 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/487 , Y02A50/489 , Y02A50/491
摘要： The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
摘要翻译： 本公开提供了包含热灭活的新月牙菌（HKCC）的免疫调节组合物。 本公开的免疫调节组合物可用于调节个体的免疫应答。 本公开因此提供调节个体的免疫应答的方法，包括向个体施用包含HKC的免疫调节组合物。
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公开(公告)号：US11065283B2
公开(公告)日：2021-07-20
申请号：US15754580
申请日：2016-08-22
申请人： Babita Agrawal , Rakesh Kumar , Nancy Gupta
发明人： Babita Agrawal , Rakesh Kumar , Nancy Gupta
摘要： The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.
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公开(公告)号：US10946082B2
公开(公告)日：2021-03-16
申请号：US16511847
申请日：2019-07-15
申请人： Babita Agrawal , Rakesh Kumar
发明人： Babita Agrawal , Rakesh Kumar
IPC分类号： A61K39/39 , A61K39/02 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/35 , A61K39/395
摘要： The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
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公开(公告)号：US20100130440A1
公开(公告)日：2010-05-27
申请号：US12467939
申请日：2009-05-18
IPC分类号： A61K31/7072 , C07H19/06 , A61P31/12
CPC分类号： C07D239/54 , C07D403/04 , C07D491/04 , C07H19/06 , C07H19/23
摘要： Disclosed are nucleosides which are useful in diagnosing and treating viral infections, for example, infections caused by hepatitis B virus (HBV), and herpes viruses including Epstein Barr virus.
摘要翻译： 公开了可用于诊断和治疗病毒感染的核苷，例如由乙型肝炎病毒（HBV）引起的感染，以及包括爱泼斯坦巴尔病毒在内的疱疹病毒。
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10.发明授权Methods of detecting T-cell activation and treating disorders associated with T-cell dysfunction 失效检测T细胞活化和治疗与T细胞功能障碍有关的疾病的方法
公开(公告)号：US6114129A
公开(公告)日：2000-09-05
申请号：US339944
申请日：1999-06-25
IPC分类号： G01N33/50 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/532 , G01N33/542 , G01N33/555 , G01N33/564 , G01N33/567 , G01N33/569 , G01N33/574 , G01N33/58
CPC分类号： G01N33/56972
摘要： Methods of detecting activated T-cells involve monitoring levels of MUC-1 mucin expression at the protein and/or mRNA level. Compositions for modulating immune function contain compounds that modulate the expression or function of MUC-1. Methods of treating disorders associated an inappropriate state of T-cell activation involve contacting a T-cell with a compound containing an inhibitor of MUC-1 expression or function.
摘要翻译： 检测活化的T细胞的方法涉及监测蛋白质和/或mRNA水平的MUC-1粘蛋白表达的水平。 用于调节免疫功能的组合物含有调节MUC-1的表达或功能的化合物。 治疗与不良状态的T细胞活化相关的疾病的方法包括使T细胞与含有MUC-1抑制剂表达或功能的化合物接触。
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