公开(公告)号：US08198298B2

公开(公告)日：2012-06-12

申请号：US13026789

申请日：2011-02-14

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： A61K31/44

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US07888508B2

公开(公告)日：2011-02-15

申请号：US11020794

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： C07D471/02 ,  C07D498/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20110136857A1

公开(公告)日：2011-06-09

申请号：US13026789

申请日：2011-02-14

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： A61K31/437 ,  A61K31/4545 ,  A61P35/00 ,  A61P25/28 ,  A61P31/12 ,  A61P37/00 ,  A61P17/06 ,  A61P9/10 ,  A61P19/02 ,  A61P17/14 ,  C12N9/99 ,  C40B40/04

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20050209269A1

公开(公告)日：2005-09-22

申请号：US11020794

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

IPC分类号： C07D471/04 ,  A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20050187209A1

公开(公告)日：2005-08-25

申请号：US11050360

申请日：2005-02-03

申请人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

发明人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

IPC分类号： A61K31/4162 ,  C07D495/04 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/496

CPC分类号： C07D495/04 ,  A61K31/4162

摘要： Thieno[2,3-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

摘要翻译： 公开了本说明书中定义的式（1）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。

公开(公告)号：US08481584B2

公开(公告)日：2013-07-09

申请号：US13404697

申请日：2012-02-24

申请人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

发明人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

IPC分类号： A61K31/4162 ,  C07D231/26

CPC分类号： C07D495/04 ,  A61K31/4162

摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

摘要翻译： 公开了本说明书中定义的式（I）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。

公开(公告)号：US20120165311A1

公开(公告)日：2012-06-28

申请号：US13404697

申请日：2012-02-24

申请人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

发明人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

IPC分类号： A61K31/4162 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61P35/00 ,  A61P25/28 ,  A61P31/12 ,  A61P37/06 ,  A61P17/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P9/00 ,  A61P19/02 ,  A61K31/55 ,  A61K31/541 ,  A61N5/00 ,  C12N9/99

CPC分类号： C07D495/04 ,  A61K31/4162

摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

摘要翻译： 公开了本说明书中定义的式（I）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。

公开(公告)号：US08138217B2

公开(公告)日：2012-03-20

申请号：US11050360

申请日：2005-02-03

申请人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

发明人： Daniele Fancelli ,  Paola Vianello ,  Mario Varasi ,  Simona Bindi ,  Sergio Vioglio ,  Dania Tesei

IPC分类号： A61K31/4162 ,  C07D231/26

CPC分类号： C07D495/04 ,  A61K31/4162

摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

摘要翻译： 公开了本说明书中定义的式（I）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。