公开(公告)号：US08198298B2

公开(公告)日：2012-06-12

申请号：US13026789

申请日：2011-02-14

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： A61K31/44

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US07888508B2

公开(公告)日：2011-02-15

申请号：US11020794

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： C07D471/02 ,  C07D498/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20110136857A1

公开(公告)日：2011-06-09

申请号：US13026789

申请日：2011-02-14

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： A61K31/437 ,  A61K31/4545 ,  A61P35/00 ,  A61P25/28 ,  A61P31/12 ,  A61P37/00 ,  A61P17/06 ,  A61P9/10 ,  A61P19/02 ,  A61P17/14 ,  C12N9/99 ,  C40B40/04

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US08106069B2

公开(公告)日：2012-01-31

申请号：US12766230

申请日：2010-04-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： A61K31/44 ,  A61K31/50 ,  A61K31/497 ,  A61K31/445

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US07728140B2

公开(公告)日：2010-06-01

申请号：US11020793

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： C07D471/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20100210476A1

公开(公告)日：2010-08-19

申请号：US12766230

申请日：2010-04-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： C40B40/04 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/496 ,  A61P35/00 ,  A61P25/28 ,  A61P31/12 ,  A61P13/08 ,  A61P17/06 ,  A61P9/10 ,  A61P19/02 ,  A61P35/04 ,  A61P37/06 ,  A61P17/14

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20050209269A1

公开(公告)日：2005-09-22

申请号：US11020794

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

IPC分类号： C07D471/04 ,  A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US20050256151A1

公开(公告)日：2005-11-17

申请号：US11020793

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

IPC分类号： C07D471/04 ,  G01N33/53 ,  A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

公开(公告)号：US07511136B2

公开(公告)日：2009-03-31

申请号：US10490189

申请日：2002-09-19

申请人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

发明人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

IPC分类号： C07D413/00 ,  C07D231/00

CPC分类号： C07D231/56 ,  C07D403/04 ,  C07D403/12

摘要： Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

摘要翻译： 公开了3-氨基吲唑衍生物或其药学上可接受的盐以及包含它们的药物组合物的化合物; 这些化合物或组合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。

公开(公告)号：US08513241B2

公开(公告)日：2013-08-20

申请号：US13482626

申请日：2012-05-29

申请人： Giovanni Cervi ,  Matteo D'Anello ,  Gianluca Mariano Enrico Papeo ,  Barbara Salom

发明人： Giovanni Cervi ,  Matteo D'Anello ,  Gianluca Mariano Enrico Papeo ,  Barbara Salom

IPC分类号： A61K31/5355 ,  A61K31/501 ,  C07D413/14 ,  C07D241/04

CPC分类号： C07D487/04

摘要： Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了3,4-二氢-2H-吡嗪并[1,2-a]吲哚-1-酮衍生物或其药学上可接受的盐，其制备方法和包含它们的药物组合物的化合物。 这些化合物可用于治疗由改变的蛋白激酶活性引起的和/或与其相关的疾病，例如癌症，病毒感染，HIV感染个体中的AIDS发展的预防，细胞增殖性疾病，自身免疫和神经变性疾病; 还公开了用于制备本发明化合物的固相合成条件和包含多个化合物的化学文库的方法。