公开(公告)号：US20120269821A1

公开(公告)日：2012-10-25

申请号：US13314712

申请日：2011-12-08

申请人： Barton F. Haynes ,  Hua-Xin Liao ,  M. Anthony Moody ,  Lynn Morris ,  Salim S. Abdool Karim

发明人： Barton F. Haynes ,  Hua-Xin Liao ,  M. Anthony Moody ,  Lynn Morris ,  Salim S. Abdool Karim

IPC分类号： C07K16/10 ,  C12N15/13 ,  C12P21/02 ,  C12N15/63 ,  C12N5/10 ,  A61K39/42 ,  A61P31/18

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates, in general, to HIV-1 antibodies and, in particular, to broadly neutralizing HIV-1 antibodies that target the gp41 membrane-proximal external region (MPER).

摘要翻译： 本发明一般涉及HIV-1抗体，尤其涉及广泛中和靶向gp41膜近端外部区域（MPER）的HIV-1抗体。

公开(公告)号：US20090270488A1

公开(公告)日：2009-10-29

申请号：US12357099

申请日：2009-01-21

申请人： Robert Edward Johnston ,  Salim Abdol Karim ,  Lynn Morris ,  Ronald Swanstrom ,  Carolyn Williamson

发明人： Robert Edward Johnston ,  Salim Abdol Karim ,  Lynn Morris ,  Ronald Swanstrom ,  Carolyn Williamson

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C07H21/02 ,  C07K14/005

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16051 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. A process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.

摘要翻译： 本发明的实施方案提供用于选择HIV-1亚型（进化枝）C分离株，选择的HIV-1亚型C分离物，其基因及其修饰和衍生物的方法，用于预防和治疗疫苗以产生用于该目的的蛋白质和多肽 引起艾滋病毒感染或疾病的保护。 选择HIV亚型分离物的方法包括从最近感染的受试者中分离病毒的步骤; 通过鉴定分离的病毒中最常见的密码子或氨基酸，产生至少一部分HIV基因的共有序列; 并选择与共有序列具有高序列同一性的分离的病毒或病毒。 还提供了称为Du422，Du 151和Du 179（分别由欧洲细胞培养物集合分配的登录号01032114，00072724和00072725）的HIV-1亚型C分离物。

公开(公告)号：US07910716B2

公开(公告)日：2011-03-22

申请号：US12357099

申请日：2009-01-21

申请人： Robert Edward Johnston ,  Salim Abdol Karim ,  Lynn Morris ,  Ronald Swanstrom ,  Carolyn Williamson

发明人： Robert Edward Johnston ,  Salim Abdol Karim ,  Lynn Morris ,  Ronald Swanstrom ,  Carolyn Williamson

IPC分类号： C07H21/04 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16051 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. A process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.

摘要翻译： 本发明的实施方案提供用于选择HIV-1亚型（进化枝）C分离株，选择的HIV-1亚型C分离物，其基因及其修饰和衍生物的方法，用于预防和治疗疫苗以产生用于该目的的蛋白质和多肽 引起艾滋病毒感染或疾病的保护。 选择HIV亚型分离物的方法包括从最近感染的受试者中分离病毒的步骤; 通过鉴定分离的病毒中最常见的密码子或氨基酸，产生至少一部分HIV基因的共有序列; 并选择与共有序列具有高序列同一性的分离的病毒或病毒。 还提供了称为Du422，Du 151和Du 179（分别由欧洲细胞培养物集合分配的登录号01032114，00072724和00072725）的HIV-1亚型C分离物。

公开(公告)号：US20070172930A1

公开(公告)日：2007-07-26

申请号：US11724551

申请日：2007-03-15

申请人： Robert Johnston ,  Salim Karim ,  Lynn Morris ,  Roland Swanstrom ,  Carolyn Williamson

发明人： Robert Johnston ,  Salim Karim ,  Lynn Morris ,  Roland Swanstrom ,  Carolyn Williamson

IPC分类号： C12Q1/68 ,  C12P19/34 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2770/36143 ,  C12N2770/36151

摘要： The invention provides a process for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. The process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.

摘要翻译： 本发明提供了选择HIV-1亚型（进化枝）C分离物，所选择的HIV-1亚型C分离株，其基因及其修饰和衍生物用于预防和治疗疫苗以产生用于产生蛋白质和多肽的目的的进程 引起艾滋病毒感染或疾病的保护。 选择HIV亚型分离物的过程包括从最近感染的受试者中分离病毒的步骤; 通过鉴定分离的病毒中最常见的密码子或氨基酸，产生至少一部分HIV基因的共有序列; 并选择与共有序列具有高序列同一性的分离的病毒或病毒。 还提供了称为Du422，Du 151和Du 179（分别由欧洲细胞培养物集合分配的登录号01032114，00072724和00072725）的HIV-1亚型C分离物。