公开(公告)号：US09174997B2

公开(公告)日：2015-11-03

申请号：US14522510

申请日：2014-10-23

申请人： Bayer Intellectual Property GmbH

发明人： Franz Von Nussbaum ,  Dagmar Karthaus ,  Sonja Anlauf ,  Martina Delbeck ,  Volkhart Min-Jian Li ,  Daniel Meibom ,  Klemens Lustig ,  Jens Schamberger

IPC分类号： A61K31/513 ,  C07D487/04 ,  C07D239/22 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D487/04 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D239/22 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.

摘要翻译： 本发明涉及新的4-（4-氰基-2-硫代芳基）二氢嘧啶-2-酮衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺和心血管系统疾病。

公开(公告)号：US09359362B2

公开(公告)日：2016-06-07

申请号：US14047458

申请日：2013-10-07

申请人： BAYER INTELLECTUAL PROPERTY GmbH

发明人： Franz Von Nussbaum ,  Dagmar Karthaus ,  Sonja Anlauf ,  Martina Delbeck ,  Volkhart Min-Jian Li ,  Daniel Meibom ,  Klemens Lustig

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  A61K45/06 ,  C07D487/14

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07D487/14

摘要： The present invention relates to novel heterocyclically fused diaryldihydropyrimidine derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.

公开(公告)号：US09687476B2

公开(公告)日：2017-06-27

申请号：US14930463

申请日：2015-11-02

申请人： Bayer Intellectual Property GmbH

发明人： Chantal Fürstner ,  Jörg Keldenich ,  Martina Delbeck ,  Peter Kolkhof ,  Axel Kretschmer ,  Ingo Pluschkell ,  Elisabeth Pook ,  Carsten Schmeck ,  Hubert Trübel

IPC分类号： A61K31/4196 ,  C07D249/12 ,  C07D401/06 ,  C07D403/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K45/06

CPC分类号： A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K45/06 ,  C07D249/12 ,  C07D401/06 ,  C07D403/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.