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1.发明授权Substituted dihydropyrazolones for treating cardiovascular and hematological diseases 有权取代二氢吡唑酮用于治疗心血管和血液疾病公开(公告)号：US08987261B2
公开(公告)日：2015-03-24
申请号：US13769513
申请日：2013-02-18
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/5377 , C07D417/14 , C07D401/14 , C07D471/04 , C07D413/14 , C07D403/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US09687476B2
公开(公告)日：2017-06-27
申请号：US14930463
申请日：2015-11-02
发明人： Chantal Fürstner , Jörg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Ingo Pluschkell , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , C07D249/12 , C07D401/06 , C07D403/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06
CPC分类号： A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D249/12 , C07D401/06 , C07D403/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06
摘要： The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
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3.发明授权Substituted 4-aryl-1,4-dihydro-1,6-naphthyridine amides and their use 有权取代的4-芳基-1,4-二氢-1,6-萘啶酰胺及其用途公开(公告)号：US09051316B2
公开(公告)日：2015-06-09
申请号：US13801376
申请日：2013-03-13
发明人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。
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公开(公告)号：US09168249B2
公开(公告)日：2015-10-27
申请号：US14613367
申请日：2015-02-04
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
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