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METHANONES](/abs-image/US/2020/03/19/US20200085791A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200085791A1
公开(公告)日：2020-03-19
申请号：US16470495
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： A61K31/4192 , A61K45/06 , A61K31/704 , C07D487/18
摘要： The present invention covers [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1H-1,2,3-triazol-5-yl)methanone compounds of general formula (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200237757A1
公开(公告)日：2020-07-30
申请号：US16303539
申请日：2017-05-23
发明人： Norbert SCHMEES , Ilona GUTCHER , Horst IRLBACHER , Benjamin BADER , Na ZHAO , Michael PLATTEN , Ulrike ROEHN , Ludwig ZORN , Lars ROESE , Detlef STOECKIGT
IPC分类号： A61K31/501 , A61K45/06 , C07D237/24 , C07D405/12 , C07D403/12 , A61K31/50 , A61P35/00
摘要： The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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3.发明申请公开(公告)号：US20170354620A1
公开(公告)日：2017-12-14
申请号：US15537280
申请日：2015-12-16
发明人： Nico BRÄUER , Jens NAGEL , Horst IRLBACHER , Andrea ROTGERI , Wolfgang SCHWEDE , Henrik DAHLLÖF , Marcus KOPPITZ , Michaele PETERS , Anne-Marie GODINHO-COELHO
IPC分类号： A61K31/167 , C07D213/61 , C07D213/56 , A61K31/44
CPC分类号： A61K31/167 , A61K31/44 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/84 , C07D405/12
摘要： The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
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公开(公告)号：US20210317092A1
公开(公告)日：2021-10-14
申请号：US16472281
申请日：2017-12-18
发明人： Stefan BÄEURLE , Adam James DAVENPORT , Christopher STIMSON , James Lindsay CARR , Christian Abingdon BUBERT , Frédéric Jacques MARLIN , Jens NAGEL , Nicole SCHMIDT , Andrea ROTGERI , Horst IRLBACHER
IPC分类号： C07D257/04 , A61P19/02 , A61P29/00 , C07D401/12 , C07D401/10 , C07D401/14 , C07D403/10 , C07D491/048 , C07D409/10
摘要： The present invention relates to tetrazole containing compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease syndrome, condition, or symptoms, in particular related to chronic pain and inflammation, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20170260226A1
公开(公告)日：2017-09-14
申请号：US15510348
申请日：2015-09-07
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06 , C07J31/003 , C07J41/0038
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
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6.发明申请NOVEL INDAZOLECARBOXAMIDES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS COMPRISING THEM AND THEIR USE FOR PRODUCING MEDICAMENTS 有权新型异氰脲酸酯，其制备方法，包含它们的药物制剂及其用于生产药物的用途公开(公告)号：US20160311833A1
公开(公告)日：2016-10-27
申请号：US15106073
申请日：2014-12-16
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Andrea ROTGERI , Ulf BÖMER , Sven RING , Horst IRLBACHER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Martina SCHÄFER
IPC分类号： C07D495/10 , C07D401/14 , C07D417/14 , C07D413/12 , C07D403/12 , C07D413/14 , C07D471/10 , C07D487/10 , C07D491/107 , C07D405/14 , C07D409/14 , C07D401/12 , C07D417/12
CPC分类号： C07D495/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/10 , C07D491/107
摘要： The present application relates to novel 6-substituted indazoles having a carboxamide side chain, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of endometriosis, lymphomas, macular degeneration, COPD and psoriasis.
摘要翻译： 本申请涉及具有羧酰胺侧链的新颖的6-取代的吲唑，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和 /或预防疾病，特别是用于治疗和/或预防子宫内膜异位，淋巴瘤，黄斑变性，COPD和牛皮癣的疾病。
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公开(公告)号：US20240294505A1
公开(公告)日：2024-09-05
申请号：US16485049
申请日：2018-02-02
发明人： Ilona GUTCHER , Ulrike RÖHN , Norbert SCHMEES , Ludwig ZORN , Lars RÖSE , Benjamin BADER , Christina KOBER , Rafael CARRETERO , Detlef STÖCKIGT , Horst IRLBACHER , Michael PLATTEN
IPC分类号： C07D403/04 , A61K31/501 , A61K31/506 , A61K45/06 , A61P35/00 , C07D237/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
CPC分类号： C07D403/04 , A61K31/501 , A61K31/506 , A61K45/06 , A61P35/00 , C07D237/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I), in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230121195A1
公开(公告)日：2023-04-20
申请号：US17819602
申请日：2022-08-12
发明人： Ilona GUTCHER , Ulrike RÖHN , Norbert SCHMEES , Ludwig ZORN , Lars RÖSE , Benjamin BADER , Christina KOBER , Rafael CARRETERO , Detlef STÖCKIGT , Horst IRLBACHER , Michael PLATTEN
IPC分类号： C07D417/04 , A61P35/00 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D409/14 , C07D401/14
摘要： The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (1): in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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METHANONES](/abs-image/US/2020/03/19/US20200087284A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200087284A1
公开(公告)日：2020-03-19
申请号：US16469745
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： C07D403/06 , A61K31/704
摘要： The present invention covers [4-(phenylsulfonyl)piperazin-1-yl](1H-1,2,3-triazol-4-yl)methanone compounds of general formula (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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METHANONES](/abs-image/US/2020/03/12/US20200079758A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200079758A1
公开(公告)日：2020-03-12
申请号：US16469861
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： C07D403/06 , A61K31/496 , A61K45/06 , A61K31/704 , C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14 , C07D405/14 , A61P35/00
摘要： The present invention covers [4-(phenylsulfonyl)piperazin-1-yl](1H-1,2,3-triazol-4-yl)methanone compounds of general formula (I): (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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