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公开(公告)号：US11286263B2
公开(公告)日：2022-03-29
申请号：US16764563
申请日：2018-11-15
发明人： Steven James Ferrara , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Laura Furst , Guo Wei , Patrick Ryan McCarren , Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning
IPC分类号： C07D487/14 , C07D403/14 , C07D498/14 , A61K31/4162 , A61P35/00
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2017/04/18/US09624214B2/abs.jpg.150x150.jpg)
公开(公告)号：US09624214B2
公开(公告)日：2017-04-18
申请号：US14070180
申请日：2013-11-01
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： A61K31/4353 , C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20210079018A1
公开(公告)日：2021-03-18
申请号：US16764563
申请日：2018-11-15
发明人： Steven J. Ferrara , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Laura Furst , Guo Wei , Patrick Ryan MacCarren , Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning
IPC分类号： C07D498/14 , C07D487/14 , A61P35/00
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20180141930A1
公开(公告)日：2018-05-24
申请号：US15847402
申请日：2017-12-19
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Volker Geiss , Andreas Göller , Herbert Himmel , Raimund Kast , Andreas Knorr , Dieter Lang , Gorden Redlich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D401/14 , A61K45/06 , A61K31/541 , A61K31/5377 , C07D491/107 , C07D417/14 , C07D413/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：US09624199B2
公开(公告)日：2017-04-18
申请号：US15106286
申请日：2014-12-16
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Andreas Göller , Herbert Himmel , Raimund Kast , Joerg Keldenich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/541 , A61K45/06 , A61K31/5377 , C07D491/107
CPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/06 , C07D403/14 , C07D413/14 , C07D491/107
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2015/09/08/US09126998B2/abs.jpg.150x150.jpg)
6.发明授权公开(公告)号：US09126998B2
公开(公告)日：2015-09-08
申请号：US13789655
申请日：2013-03-07
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva-Maria Becker , Andreas Knorr
IPC分类号： A61K31/439 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20200087322A1
公开(公告)日：2020-03-19
申请号：US16301871
申请日：2017-05-17
发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Fernandez-Montalvan , Nicolas Werbeck , Ursula Moenning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick R. McCarren
IPC分类号： C07D498/16 , C07D487/16 , C07D498/22 , C07D498/06
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10323020B2
公开(公告)日：2019-06-18
申请号：US15847402
申请日：2017-12-19
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Volker Geiss , Andreas Göller , Herbert Himmel , Raimund Kast , Andreas Knorr , Dieter Lang , Gorden Redlich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D413/14 , C07D401/14 , C07D417/14 , C07D491/107 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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![3-aryl-substituted imidazo[1,2-A]pyridines and their use](/abs-image/US/2017/10/03/US09776997B2/abs.jpg.150x150.jpg)
公开(公告)号：US09776997B2
公开(公告)日：2017-10-03
申请号：US14895809
申请日：2014-06-04
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Alexey Gromov , Niels Lindner , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li
IPC分类号： A61K31/437 , C07D471/04 , A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： The present application relates to novel 3-aryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
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![Cyano-substituted imidazo[1,2-A]pyridinecarboxamides and their use](/abs-image/US/2017/09/26/US09771360B2/abs.jpg.150x150.jpg)
公开(公告)号：US09771360B2
公开(公告)日：2017-09-26
申请号：US15120377
申请日：2015-03-18
发明人： Alexandros Vakalopoulos , Philipp Buchgraber , Niels Lindner , Markus Follmann , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Gorden Redlich , Lisa Dietz , Volkhart Min-Jian Li
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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