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    SUBSTITUTED DIHYDROPYRIDO[3,4-B]PYRAZINONES AS DUAL INHIBITORS OF BET PROTEINS AND POLO-LIKE KINASES
    5.
    发明申请
    SUBSTITUTED DIHYDROPYRIDO[3,4-B]PYRAZINONES AS DUAL INHIBITORS OF BET PROTEINS AND POLO-LIKE KINASES 审中-公开
    取代的二氢吡咯并[3,4-B]吡啶酮作为BET蛋白和类似动物的双重抑制剂

    公开(公告)号：US20160272635A1

    公开(公告)日：2016-09-22

    申请号：US14907367

    申请日：2014-07-21

    申请人： BAYER PHARMA AKTIENGESELLSCHAFT

    发明人： Norbert Schmees ,  Benjamin Bader ,  Bernard Haendler ,  Volker Schulze ,  Ingo Hartung ,  Niels Bohnke ,  Florian Puehler

    IPC分类号： C07D471/04 ,  A61K31/55 ,  A61K31/4985

    CPC分类号： C07D471/04 ,  A61K31/4985 ,  A61K31/55

    摘要： The present invention relates to substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of BET proteins, in particular BRD4 proteins, and Polo-like kinases, in particular Plk-1 proteins of the general formula (I) in which A, X, R1, R2, R3, R4, R5, R6, R7 and n are each as defined in the description, to intermediates for preparation of the compounds according to the invention, to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of tumour disorders.Furthermore, the present invention relates to the use of the dihydropyrido[3,4-b]pyrazinones according to the invention in viral infections, in neurodegenerative disorders, in inflammation disorders, in atherosclerotic disorders and in male fertility control.

    摘要翻译： 此外，本发明涉及根据本发明的二氢吡啶并[3,4-b]吡嗪酮在病毒感染，神经退行性疾病，炎性疾病，动脉粥样硬化疾病和雄性生育控制中的用途。