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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2017/04/18/US09624214B2/abs.jpg.150x150.jpg)
公开(公告)号：US09624214B2
公开(公告)日：2017-04-18
申请号：US14070180
申请日：2013-11-01
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： A61K31/4353 , C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20180141930A1
公开(公告)日：2018-05-24
申请号：US15847402
申请日：2017-12-19
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Volker Geiss , Andreas Göller , Herbert Himmel , Raimund Kast , Andreas Knorr , Dieter Lang , Gorden Redlich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D401/14 , A61K45/06 , A61K31/541 , A61K31/5377 , C07D491/107 , C07D417/14 , C07D413/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2015/09/08/US09126998B2/abs.jpg.150x150.jpg)
3.发明授权公开(公告)号：US09126998B2
公开(公告)日：2015-09-08
申请号：US13789655
申请日：2013-03-07
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva-Maria Becker , Andreas Knorr
IPC分类号： A61K31/439 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use](/abs-image/US/2020/05/26/US10662185B2/abs.jpg.150x150.jpg)
公开(公告)号：US10662185B2
公开(公告)日：2020-05-26
申请号：US16025087
申请日：2018-07-02
发明人： Alexandros Vakalopoulos , Markus Follman , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haßfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/55 , A61K31/4375 , A61K31/4725
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides of the general formula (I) to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2015/10/01/US20150274719A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20150274719A1
公开(公告)日：2015-10-01
申请号：US14440509
申请日：2013-11-04
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Hassfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K31/496 , A61K31/541 , A61K31/4985 , C07D519/00 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE](/abs-image/US/2015/06/04/US20150152050A1/abs.jpg.150x150.jpg)
6.发明申请N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE 有权N- [3-（2-羧基乙基）苯基]哌啶-1-基乙酰胺衍生物及其作为可溶性葡萄糖酸环化酶的活化剂的用途公开(公告)号：US20150152050A1
公开(公告)日：2015-06-04
申请号：US14402232
申请日：2013-05-17
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Friederike Stoll , Andreas Knorr
IPC分类号： C07D211/14 , A61K45/06 , A61K31/472 , A61K31/438 , A61K31/451 , C07D217/04 , A61K31/445 , C07D221/20
CPC分类号： C07D211/14 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/472 , A61K45/06 , C07D211/06 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15
摘要： The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的2-（哌啶-1-基）乙酰胺衍生物，其制备方法及其用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和 /或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US10323020B2
公开(公告)日：2019-06-18
申请号：US15847402
申请日：2017-12-19
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Volker Geiss , Andreas Göller , Herbert Himmel , Raimund Kast , Andreas Knorr , Dieter Lang , Gorden Redlich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D413/14 , C07D401/14 , C07D417/14 , C07D491/107 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：US10035818B2
公开(公告)日：2018-07-31
申请号：US15472476
申请日：2017-03-29
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US09624198B2
公开(公告)日：2017-04-18
申请号：US15106283
申请日：2014-12-16
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Volker Geiss , Andreas Göller , Herbert Himmel , Raimund Kast , Andreas Knorr , Dieter Lang , Gorden Redlich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D401/14 , A61K31/4725 , C07D413/14 , C07D491/107 , C07D495/10 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
CPC分类号： C07D401/14 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D491/107 , C07D495/10
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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![Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2015/02/03/US08946215B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US08946215B2
公开(公告)日：2015-02-03
申请号：US14071274
申请日：2013-11-04
发明人： Alexandros Vakalopoulos , Ingo Hartung , Markus Follmann , Rolf Jautelat , Alexander Straub , Jorma Haβfeld , Niels Lindner , Dirk Schneider , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D401/02 , C07D401/10 , A61K31/4353 , C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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