公开(公告)号：US07132081B2

公开(公告)日：2006-11-07

申请号：US10296056

申请日：2001-04-27

申请人： Beate Diefenbach ,  Holger Deppe ,  Hanns Wurziger ,  Alexander Gross ,  Gregor Schlingloff ,  Andreas Schober ,  Dirk Tomandl

发明人： Beate Diefenbach ,  Holger Deppe ,  Hanns Wurziger ,  Alexander Gross ,  Gregor Schlingloff ,  Andreas Schober ,  Dirk Tomandl

IPC分类号： B01L3/00

CPC分类号： B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00333 ,  B01J2219/00585 ,  B01L3/50857 ,  B01L2300/0819 ,  C40B60/14

摘要： Microwells, which are open on both sides and are arranged two-dimensionally in a microwell matrix (4), are hermetically closed by pressure on both sides using plugs (6) covered with a sealing sheet (11). A layer of elastic material (9), which is arranged between the plug (6) and the sealing sheet (11), guarantees uniform pressure on all the microwells of a microwell matrix (4) which is loosely held by a frame structure (1). Continuous peripheral elevations (2), which protrude in both directions at right angles to the plane of the microwell matrix (4), ensure that the deformable thin layer of elastic material (9) does not escape sideways between the plug (6) and the microwell matrix (4) during the pressing process. A plurality of microwell matrices (4) are held simultaneously by the frame structure (1) and are hermetically closed by a corresponding number of allocated plugs (6), which are fastened to a base plate (7) and a cover plate (8), respectively.

摘要翻译： 在两侧开口并且在微孔矩阵（4）中二维布置的微孔通过用密封片（11）覆盖的塞子（6）在两侧通过压力气密封闭。 布置在塞子（6）和密封片（11）之间的一层弹性材料（9）保证了均匀的压力，所述的微孔基体（4）的所有微孔被框架结构（1）松动地保持 ）。 在与微孔矩阵（4）的平面成直角的两个方向上突出的连续周边高度（2）确保弹性材料（9）的可变形薄层不会在插头（6）和 微孔基质（4）。 多个微孔矩阵（4）由框架结构（1）同时保持，并被相应数量的分配的塞子（6）气密地封闭，该插头固定到基板（7）和盖板（8）上， ， 分别。