利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

46 条记录 (耗时 0.101 秒)

    Enzyme Regulating Ether Lipid Signaling Pathways
    1.
    发明申请
    Enzyme Regulating Ether Lipid Signaling Pathways 有权
    酶调节醚脂质信号通路

    公开(公告)号：US20130164758A1

    公开(公告)日：2013-06-27

    申请号：US13585298

    申请日：2012-08-14

    申请人： Benjamin F. Cravatt ,  Kyle P. Chiang ,  Sherry Niessen ,  Alan Saghatelian

    发明人： Benjamin F. Cravatt ,  Kyle P. Chiang ,  Sherry Niessen ,  Alan Saghatelian

    IPC分类号： G01N33/92

    CPC分类号： A61K31/325 ,  C12Q1/34 ,  G01N33/92 ,  G01N2500/02

    摘要： A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.

    摘要翻译： 使用结合基于活性的蛋白质组学和代谢组学的多维分析策略来确定在侵袭性癌细胞中高度升高的先前未表征的酶的活性蛋白质作为桥联血小板激活的醚脂质信号传导网络中的中心节点 因子和溶血磷脂。 生物化学研究证实，活性蛋白通过水解代谢中间体2-乙酰基单烷基甘油来调节该途径。 活性蛋白的失活破坏了癌细胞中的醚类脂质代谢，体内细胞迁移和肿瘤生长受损。

    Enzyme regulating ether lipid signaling pathways
    2.
    发明授权
    Enzyme regulating ether lipid signaling pathways 有权
    酶调节醚脂质信号通路

    公开(公告)号：US08940497B2

    公开(公告)日：2015-01-27

    申请号：US13585298

    申请日：2012-08-14

    申请人： Benjamin F. Cravatt ,  Kyle P. Chiang ,  Sherry Niessen ,  Alan Saghatelian

    发明人： Benjamin F. Cravatt ,  Kyle P. Chiang ,  Sherry Niessen ,  Alan Saghatelian

    IPC分类号： A61K31/325 ,  C12Q1/34 ,  G01N25/02 ,  G01N33/92

    CPC分类号： A61K31/325 ,  C12Q1/34 ,  G01N33/92 ,  G01N2500/02

    摘要： A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.

    摘要翻译： 使用结合基于活性的蛋白质组学和代谢组学的多维分析策略来确定在侵袭性癌细胞中高度升高的先前未表征的酶的活性蛋白质作为桥联血小板激活的醚脂质信号传导网络中的中心节点 因子和溶血磷脂。 生物化学研究证实，活性蛋白通过水解代谢中间体2-乙酰基单烷基甘油来调节该途径。 活性蛋白的失活破坏了癌细胞中的醚类脂质代谢，体内细胞迁移和肿瘤生长受损。

    ENZYME REGULATING ETHER LIPID SIGNALING PATHWAYS
    3.
    发明申请
    ENZYME REGULATING ETHER LIPID SIGNALING PATHWAYS 审中-公开
    酶调节脂肪信号通路

    公开(公告)号：US20090068107A1

    公开(公告)日：2009-03-12

    申请号：US11866349

    申请日：2007-10-02

    申请人： Benjamin F. Cravatt ,  Kyle P. Chiang ,  Sherry Niessen ,  Alan Saghatelian

    发明人： Benjamin F. Cravatt ,  Kyle P. Chiang ,  Sherry Niessen ,  Alan Saghatelian

    IPC分类号： A61K49/00 ,  A61K31/27 ,  C12Q1/68 ,  A61P31/00 ,  G01N33/00 ,  C12N5/06

    CPC分类号： A61K31/325 ,  C12Q1/34 ,  G01N33/92 ,  G01N2500/02

    摘要： A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.

    摘要翻译： 使用结合基于活性的蛋白质组学和代谢组学的多维分析策略来确定在侵袭性癌细胞中高度升高的先前未表征的酶的活性蛋白质作为桥联血小板激活的醚脂质信号传导网络中的中心节点 因子和溶血磷脂。 生物化学研究证实，活性蛋白通过水解代谢中间体2-乙酰基单烷基甘油来调节该途径。 活性蛋白的失活破坏了癌细胞中的醚类脂质代谢，体内细胞迁移和肿瘤生长受损。