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公开(公告)号：US08828395B2
公开(公告)日：2014-09-09
申请号：US13162559
申请日：2011-06-16
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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公开(公告)号：US08404471B2
公开(公告)日：2013-03-26
申请号：US12492925
申请日：2009-06-26
申请人： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
发明人： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
CPC分类号： A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
摘要： Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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公开(公告)号：US09127268B2
公开(公告)日：2015-09-08
申请号：US13514952
申请日：2010-12-10
申请人： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
发明人： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
IPC分类号： C12N9/00 , A61K38/53 , A61K39/395 , A61K45/06
CPC分类号： A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
摘要： Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
摘要翻译： 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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公开(公告)号：US20120064082A1
公开(公告)日：2012-03-15
申请号：US13162559
申请日：2011-06-16
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , A61P7/00 , C07K16/18
CPC分类号： C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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5.发明申请COMPOSITIONS AND METHODS COMPRISING GLYCYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含非经典生物活性的GLYCYL-tRNA合成酶的组合物和方法公开(公告)号：US20100028352A1
公开(公告)日：2010-02-04
申请号：US12492925
申请日：2009-06-26
申请人： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
发明人： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
IPC分类号： A61K39/395 , C12N9/00 , C07H21/04 , C12N15/63 , C12N5/00 , C12N5/02 , A61K38/43 , A61K31/7088 , C12Q1/68 , G01N33/53 , G01N33/573
CPC分类号： A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
摘要： Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译： 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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公开(公告)号：US20130108630A1
公开(公告)日：2013-05-02
申请号：US13514952
申请日：2010-12-10
申请人： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
发明人： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
IPC分类号： A61K38/53 , A61K45/06 , A61K39/395
CPC分类号： A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
摘要： Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
摘要翻译： 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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公开(公告)号：US20110150885A1
公开(公告)日：2011-06-23
申请号：US12965655
申请日：2010-12-10
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , A61K38/53 , C12N5/078 , A61K35/12 , C07H21/00 , C12N15/63 , C12N5/10 , C12N9/00 , C07K16/18 , C07K14/00 , A61P7/00
CPC分类号： A61K38/53 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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