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1.发明授权Engineered imine reductases and methods for the reductive animation of ketone and amine compounds 有权酮和胺化合物的还原动力的工程亚胺还原酶和方法公开(公告)号：US09193957B2
公开(公告)日：2015-11-24
申请号：US13890944
申请日：2013-05-09
Applicant: Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
Inventor： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt Huisman , Scott Novick , Nicholas Agard , Oscar Alvizo , Gregory Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC: C12N9/06 , C12P13/00 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
CPC classification number: C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Abstract translation: 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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2.发明授权公开(公告)号：US09102963B2
公开(公告)日：2015-08-11
申请号：US14110964
申请日：2012-04-12
Applicant: Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
Inventor： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
IPC: C12P17/10 , C12N9/02 , C07D223/22 , C07D223/28 , C07D453/02 , C12P41/00 , C12N9/04
CPC classification number: C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
Abstract translation: 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。
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公开(公告)号：US09040262B2
公开(公告)日：2015-05-26
申请号：US13695856
申请日：2011-05-04
Applicant: Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
Inventor： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC classification number: C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
Abstract translation: 本公开涉及可用于制备依泽替米贝的非天然存在的多肽，编码多肽的多核苷酸以及使用多肽的方法。
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Patent Agency Ranking
4.发明申请公开(公告)号：US20140199735A1
公开(公告)日：2014-07-17
申请号：US14110964
申请日：2012-04-12
Applicant: Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
Inventor： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
IPC: C12P17/10
CPC classification number: C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
Abstract translation: 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。
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5.发明申请Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. 有权酮和胺化合物的还原动力的工程亚胺还原酶和方法。公开(公告)号：US20130302859A1
公开(公告)日：2013-11-14
申请号：US13890944
申请日：2013-05-09
Applicant: CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
Inventor： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
IPC: C12N9/00
CPC classification number: C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Abstract translation: 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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公开(公告)号：US20130052699A1
公开(公告)日：2013-02-28
申请号：US13695856
申请日：2011-05-04
Applicant: Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
Inventor： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC classification number: C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
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公开(公告)号：US20110111468A1
公开(公告)日：2011-05-12
申请号：US12890134
申请日：2010-09-24
Applicant: Lynne GILSON , Steven James COLLIER , Joly SUKUMARAN , Wan Lin YEO , Oscar ALVIZO , Ee Ling TEO , Robert John WILSON , Junye XU
Inventor： Lynne GILSON , Steven James COLLIER , Joly SUKUMARAN , Wan Lin YEO , Oscar ALVIZO , Ee Ling TEO , Robert John WILSON , Junye XU
CPC classification number: C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
Abstract translation: 本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶
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公开(公告)号：US08383382B2
公开(公告)日：2013-02-26
申请号：US12890134
申请日：2010-09-24
Applicant: Lynne Gilson , Steven James Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert John Wilson , Junye Xu
Inventor： Lynne Gilson , Steven James Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert John Wilson , Junye Xu
CPC classification number: C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
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