公开(公告)号：US07196104B2

公开(公告)日：2007-03-27

申请号：US10631423

申请日：2003-07-30

申请人： Benny C. Askew, Jr. ,  Frenel F. De Morin ,  Andrew Hague ,  Ellen Laber ,  Aiwen Li ,  Gang Liu ,  Patricia Lopez ,  Rana Nomak ,  Vincent Santora ,  Christopher Tegley ,  Kevin Yang

发明人： Benny C. Askew, Jr. ,  Frenel F. De Morin ,  Andrew Hague ,  Ellen Laber ,  Aiwen Li ,  Gang Liu ,  Patricia Lopez ,  Rana Nomak ,  Vincent Santora ,  Christopher Tegley ,  Kevin Yang

IPC分类号： A61K31/44 ,  C07D417/12

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/06 ,  C07D471/04 ,  C07D491/10

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选择的新型尿素化合物对于预防和治疗诸如细胞增殖或细胞凋亡介导的疾病的疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及stoke，癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US06645990B2

公开(公告)日：2003-11-11

申请号：US10077124

申请日：2002-02-15

申请人： Benny C. Askew ,  Frenel F. De Morin ,  Andrew Hague ,  Ellen Laber ,  Aiwen Li ,  Gang Liu ,  Patricia Lopez ,  Rana Nomak ,  Vincent Santora ,  Christopher Tegley ,  Kevin Yang

发明人： Benny C. Askew ,  Frenel F. De Morin ,  Andrew Hague ,  Ellen Laber ,  Aiwen Li ,  Gang Liu ,  Patricia Lopez ,  Rana Nomak ,  Vincent Santora ,  Christopher Tegley ,  Kevin Yang

IPC分类号： C07D21126

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/06 ,  C07D471/04 ,  C07D491/10

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US20080004263A1

公开(公告)日：2008-01-03

申请号：US10591061

申请日：2005-03-03

申请人： Vincent Santora ,  Jonathan Covel ,  Rena Hayashi ,  Robert Webb

发明人： Vincent Santora ,  Jonathan Covel ,  Rena Hayashi ,  Robert Webb

IPC分类号： A61K31/4545 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/541 ,  A61P15/10 ,  C07D211/82 ,  C07D221/00 ,  C07D279/12 ,  C07D413/14 ,  C12N5/02

CPC分类号： C07D417/14

摘要： The present invention relates to compounds Formula I (I) that are modulators of the follicle stimulating hormone (FSH) receptor and are useful in the treatment of infertility and related disorders.

摘要翻译： 本发明涉及作为促卵泡激素（FSH）受体的调节剂的式I（I）化合物，并且可用于治疗不育症和相关疾病。