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    Process for the reactivation of iodine-containing catalysts
    7.
    发明授权
    Process for the reactivation of iodine-containing catalysts 失效
    含碘催化剂再活化方法

    公开(公告)号：US5693833A

    公开(公告)日：1997-12-02

    申请号：US701932

    申请日：1996-08-26

    申请人： Stephen Neal Falling ,  Patricia Lopez

    发明人： Stephen Neal Falling ,  Patricia Lopez

    IPC分类号： B01J38/48 ,  B01J31/40 ,  B01J38/54 ,  C07D307/28 ,  C07F7/22 ,  B01J20/34

    CPC分类号： B01J31/122 ,  B01J31/4015 ,  C07D307/28 ,  C07F7/2216 ,  B01J2231/52 ,  B01J2531/42 ,  B01J27/08 ,  Y02P20/584

    摘要： Disclosed is a process for converting an iodine-free organotin (IV) compound resulting from the decomposition of an organotin (IV) iodide during the catalytic isomerization of .gamma.,.delta.-epoxyalkenes to 2,5-dihydrofurans to the corresponding, catalytically active organotin (IV) iodide by intimately contacting a catalyst mixture comprising (i) an organotin (IV) iodide, (ii) an iodine-free organotin (IV) compound resulting from the decomposition of the organotin (IV) iodide of component (i), and (iii) a solvent selected from hydrocarbons and chlorocarbons with aqueous hydrogen iodide.

    摘要翻译： 本发明公开了一种在γ，δ-环氧乙烷催化异构化至2,5-二氢呋喃期间将碘化有机锡（Ⅳ）分解产生的无碘有机锡（Ⅳ）化合物转化为相应的催化活性有机锡（ IV）碘化物，其通过紧密接触催化剂混合物，所述催化剂混合物包含（i）碘化有机锡（IV），（ii）由组分（i）的有机锡（IV）碘化物分解得到的无碘有机锡（IV）化合物和 （iii）选自烃和氯代烃的溶剂与碘化氢水溶液。

    Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use
    10.
    发明申请
    Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use 有权
    氨基杂芳基化合物作为β-分泌酶调节剂和使用方法

    公开(公告)号：US20130018064A1

    公开(公告)日：2013-01-17

    申请号：US13511360

    申请日：2010-11-19

    申请人： Nick A. Paras ,  Yuan Cheng ,  Timothy Powers ,  James Brown ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Qiufen Xue ,  Bryant Yang

    发明人： Nick A. Paras ,  Yuan Cheng ,  Timothy Powers ,  James Brown ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Qiufen Xue ,  Bryant Yang

    IPC分类号： A61K31/506 ,  A61P25/28 ,  A61K31/4709 ,  C07D401/08 ,  C07D401/06

    CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D401/14

    摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

    摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，环Z，m和p如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。