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公开(公告)号：US07662811B2
公开(公告)日：2010-02-16
申请号：US11182216
申请日：2005-07-15
申请人： Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
发明人： Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
IPC分类号： A01N43/00 , A61K31/00 , A61K31/55 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D221/10 , C07D221/08 , C07D239/74 , C07D241/08 , C07D243/08 , C07D249/08 , C07D295/135 , C07D311/96 , C07D335/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D491/04
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20090227601A1
公开(公告)日：2009-09-10
申请号：US12085872
申请日：2006-12-06
申请人： Jiawang Zhu , Jian Jeffrey Chen , Jason B. Human , Wenyuan Qian
发明人： Jiawang Zhu , Jian Jeffrey Chen , Jason B. Human , Wenyuan Qian
IPC分类号： A61K31/497 , C07D401/06 , C07D401/14 , A61P29/00
CPC分类号： C07D401/12 , C07D241/08 , C07D401/14 , C07D403/12 , C07D405/12 , C07D453/02 , C07D487/08 , C07D487/10
摘要： The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译： 本发明包括新颖的化合物及其药学上可接受的衍生物，用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。
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公开(公告)号：US09126935B2
公开(公告)日：2015-09-08
申请号：US13058616
申请日：2009-08-07
IPC分类号： A61K31/505 , A61K31/44 , A61K31/47 , C07D239/02 , C07D215/04 , C07D213/78 , C07D471/02 , C07D215/22 , C07D239/34
CPC分类号： C07D215/22 , C07D239/34
摘要： The present invention relates to chemical compounds having a general formula I wherein A1-6, L1, R1, R4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译： 本发明涉及具有通式I的化合物，其中A1-6，L1，R1，R4-6和n定义在本文中，以及合成中间体，其能够调节各种蛋白激酶受体酶，从而影响各种 与这些激酶活性有关的疾病状态和病症。 例如，化合物能够调节Aurora激酶，从而影响细胞周期和细胞增殖的过程，以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物，包括治疗与Aurora激酶活性相关的疾病状态的化合物和方法。
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公开(公告)号：US20110294837A1
公开(公告)日：2011-12-01
申请号：US13058616
申请日：2009-08-07
IPC分类号： A61K31/505 , C07D213/81 , C07D239/47 , A61P35/02 , A61K31/47 , A61K31/44 , A61K31/4375 , A61P35/00 , C07D215/233 , C07D471/04
CPC分类号： C07D215/22 , C07D239/34
摘要： The present invention relates to chemical compounds having a general formula I wherein A1-6, L1, R1, R4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译： 本发明涉及具有通式I的化合物，其中A1-6，L1，R1，R4-6和n定义在本文中，以及合成中间体，其能够调节各种蛋白激酶受体酶，从而影响各种 与这些激酶活性有关的疾病状态和病症。 例如，化合物能够调节Aurora激酶，从而影响细胞周期和细胞增殖的过程，以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物，包括治疗与Aurora激酶活性相关的疾病状态的化合物和方法。
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