公开(公告)号：US20120237964A1

公开(公告)日：2012-09-20

申请号：US13422374

申请日：2012-03-16

Applicant: Benzhong TANG ,  Yang Liu ,  Wing Yip Lam ,  Yong Yu

Inventor： Benzhong TANG ,  Yang Liu ,  Wing Yip Lam ,  Yong Yu

IPC: G01N21/64 ,  C09B62/343 ,  C07D207/448

CPC classification number: C07D207/444 ,  C07D207/448 ,  C09B57/00 ,  C09B69/008 ,  Y10T436/182

Abstract: Provided herein are a luminogen compound of formula (I) including a AIE luminophore moiety conjugated with a maleimide moiety and a use of the same for detecting thiol groups in biomolecules. Also provided is a dye molecule, a biosensor or a bioprobe comprising the luminogen compound of formula (I) in use for detecting thiol groups in biomolecules. The detection method of the present subject matter not only has high thio-selectivity and sensitivity, but also is rapid, convenient and handy.

Abstract translation: 本文提供式（I）的发光剂化合物，其包含与马来酰亚胺部分缀合的AIE发光体部分，以及用于检测生物分子中的硫醇基团的用途。 还提供了染料分子，生物传感器或生物探针，其包含用于检测生物分子中硫醇基团的式（I）的发光剂化合物。 本发明的检测方法不仅具有高硫选择性和灵敏度，而且快速，方便，方便。

公开(公告)号：US20120282703A1

公开(公告)日：2012-11-08

申请号：US13462183

申请日：2012-05-02

Applicant: Benzhong TANG ,  Yi LIU ,  Jingzhi SUN ,  Anjun QIN ,  Rongrong HU

Inventor： Benzhong TANG ,  Yi LIU ,  Jingzhi SUN ,  Anjun QIN ,  Rongrong HU

IPC: G01N21/64

CPC classification number: C12Q1/54 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/52 ,  G01N33/582 ,  G01N33/66 ,  G01N2021/6439 ,  Y10T436/144444

Abstract: A method of detecting the presence or absence of saccharide or saccharide level in a biological or artificial sample comprising contacting the sample with a water-soluble tetraphenylethene-cored probe having multiple functionalities of boronic acid and aggregation induced emission (AIE) characteristics, and detecting fluorescence. A method for detecting pH in a sample solution with a certain pH value comprising contacting the sample solution with a water-soluble tetraphenylethene-cored probe having multiple functionalities of boronic acid and aggregation induced emission (AIE) characteristics, and detecting fluorescence.

Abstract translation: 一种检测生物或人造样品中糖或糖含量的存在或不存在的方法，包括使样品与具有多种硼酸功能性和聚集诱导发射（AIE）特征的水溶性四苯乙烯 - 核心探针接触，并检测荧光 。 一种用于检测具有一定pH值的样品溶液中的pH的方法，包括使样品溶液与具有多种硼酸官能度和聚集诱导发射（AIE）特性的水溶性四苯乙烯 - 核心探针接触，并检测荧光。

公开(公告)号：US20150376112A1

公开(公告)日：2015-12-31

申请号：US14752481

申请日：2015-06-26

Applicant: Benzhong TANG

Inventor： Benzhong TANG ,  Yee Yung YU ,  Tsz Kin KWOK ,  Ju MEI

IPC: C07C205/34 ,  C07C37/02 ,  C07C201/12

CPC classification number: C07C205/34 ,  C09B11/00 ,  C09B11/04 ,  C09B23/0075 ,  C09B23/141 ,  C09B23/145 ,  C09B69/008

Abstract: A photoactivatable caged compound (TPE-C) with AIE characteristics is designed and synthesized. TPE-C is non-emissive either in solution or in aggregated state, but its luminescence can be induced to emit strong cyan emission in aggregated state by UV irradiation. Such property enables TPE-C to be applied in photo-patterning and anti-counterfeiting related areas.

Abstract translation: 设计并合成了具有AIE特性的可光活化的笼状化合物（TPE-C）。 TPE-C在溶液或聚集状态下不发光，但是其发光可以通过紫外线照射在聚集状态下被诱导发出强烈的青色发射。 这样的性能使得TPE-C可以应用于光图案化和防伪相关领域。

公开(公告)号：US20130059392A1

公开(公告)日：2013-03-07

申请号：US13602641

申请日：2012-09-04

Applicant: Benzhong TANG ,  Yuning HONG ,  Wai Tung LEUNG

Inventor： Benzhong TANG ,  Yuning HONG ,  Wai Tung LEUNG

IPC: C07D401/14 ,  G01N21/64

CPC classification number: G01N21/643 ,  G01N21/3103 ,  G01N31/22 ,  G01N33/0045 ,  G01N33/1813 ,  G01N33/20 ,  G01N33/84 ,  G01N2021/6417

Abstract: Pyridine-containing polyenes and their applications as metal ion sensors. These polyenes are practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions in aqueous solutions or thin films in the solid state, due to aggregation-induced emission (AIE). The nanoaggregates of these compounds can work as “turn-off” fluorescent chemosensors for metal ions and display different fluorescence responses to various metal ions. For example, a characteristic red shift in the emission spectra is observed with a terpyridine-containing luminogen in the presence of Zn2+. However, the terpyridine-containing luminogen displays a magenta color upon selectively binding with Fe2+. This allows easy identification of both Zn2+ and Fe2+ ions in aqueous media. The function of the polyenes can be easily tuned by altering the substituent groups. Due to their AIE properties, these polyenes can be used in aqueous solutions and in solid substrates for metal sensing.

Abstract translation: 含吡啶的多烯及其作为金属离子传感器的应用。 这些多烯在溶液状态下实际上是非发光的，但由于聚集诱发发射（AIE），在固体状态的水溶液或薄膜中作为纳米颗粒悬浮液而变得高度发射。 这些化合物的纳米聚集体可用作金属离子的截止荧光化学传感器，并显示对各种金属离子的不同荧光响应。 例如，在Zn 2+的存在下，用含三联吡啶的发光体观察到发射光谱中的特征红移。 然而，含三联吡啶的发光体在选择性地与Fe2 +结合时显示品红色。 这允许在水性介质中容易地鉴定Zn 2+和Fe 2+离子。 可以通过改变取代基来容易地调节多烯的功能。 由于它们的AIE性质，这些多烯可以用于水溶液和用于金属感测的固体基质中。

公开(公告)号：US20120172296A1

公开(公告)日：2012-07-05

申请号：US13359514

申请日：2012-01-27

Applicant: Benzhong TANG ,  Yuning HONG ,  Sijie CHEN ,  Ryan Tsz Kin KWOK

Inventor： Benzhong TANG ,  Yuning HONG ,  Sijie CHEN ,  Ryan Tsz Kin KWOK

IPC: A61K38/28 ,  C07K14/62 ,  A61K38/02 ,  G01N21/76 ,  A61P3/10 ,  C07K14/435 ,  C07K14/00

CPC classification number: G01N21/6428 ,  G01N33/542 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2333/4709 ,  G01N2333/62

Abstract: The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.

Abstract translation: 目前描述的主题涉及表现出聚集诱导发射的水溶性共轭多烯化合物及其衍生物，以及任何水分散性，荧光，聚合物微粒，纳米颗粒和/或药物组合物，其包含水溶性共轭 多烯化合物和/或其衍生物。 还提供制备和使用目前描述的主题的化合物，衍生物和颗粒的方法。 目前描述的水溶性共轭多烯化合物可用作检测生物大分子，在制造传感器中，用于体外和体内监测和阻滞淀粉样蛋白原纤维形成以及开发抗癌药物的生物探针。

公开(公告)号：US20110171448A1

公开(公告)日：2011-07-14

申请号：US12984886

申请日：2011-01-05

Applicant: Benzhong TANG ,  Youhong TANG ,  Ka Wai JIM ,  Anjun QIN ,  Wing Yip LAM ,  Jie LI

Inventor： Benzhong TANG ,  Youhong TANG ,  Ka Wai JIM ,  Anjun QIN ,  Wing Yip LAM ,  Jie LI

IPC: C08G73/08 ,  B05D3/10

CPC classification number: C08G73/08 ,  C09J5/02 ,  C09J179/06 ,  C09J2400/163 ,  C09J2400/166 ,  C09J2479/02

Abstract: Provided is a high temperature-resistant metal adhesive containing hyperbranched poly(triazole)s synthesized by in situ azide/alkyne click polymerization. Also provided is a method for preparing the same adhesives by in situ click polymerization of azide and alkyne monomers on metal substrates. The method is optimized to get high adhesive strength at room temperature or elevated temperatures by analyzing the effects of monomer ratio, curing temperature and time, and annealing temperature and time. The hyberbranched poly(triazole)s adhesive has comparable or better temperature resistance compared with known high temperature epoxy metal adhesives, and it is the first high temperature metal adhesive using hyperbranched poly(triazole)s prepared by in situ azide/alkyne click polymerization.

Abstract translation: 提供含有通过原位叠氮化物/炔烃聚合合成的超支化聚（三唑）的耐高温金属粘合剂。 还提供了通过在金属基底上原位点击叠氮化物和炔单体来制备相同粘合剂的方法。 该方法通过分析单体比例，固化温度和时间以及退火温度和时间的影响，在室温或高温下得到高粘合强度。 与已知的高温环氧金属粘合剂相比，支链聚（三唑）粘合剂具有相当或更好的耐温性，并且是使用通过原位叠氮化物/炔烃聚合制备的超支化聚（三唑）的第一种高温金属粘合剂。