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公开(公告)号：US20200292548A1
公开(公告)日：2020-09-17
申请号：US16783238
申请日：2020-02-06
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Lixia Zhang , Eric Milliman , Shiv Srivastava , Albert Dobi , Jennifer Cullen
IPC分类号： G01N33/574
摘要： Methods for diagnosing the presence of BCR in prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of BCR. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
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2.发明申请公开(公告)号：US20220107322A1
公开(公告)日：2022-04-07
申请号：US17343538
申请日：2021-06-09
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Yezhou Sun , Shiv Srivastava , Albert Dobi
IPC分类号： G01N33/574 , A61K31/00 , C12Q1/6886 , G01R33/46 , G01N21/31 , G01N30/02 , C07C229/12
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
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公开(公告)号：US20210080466A1
公开(公告)日：2021-03-18
申请号：US16913775
申请日：2020-06-26
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Lixia Zhang , Shiv Srivastava , Albert Dobi , Jennifer Cullen
IPC分类号： G01N33/574
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
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4.发明申请公开(公告)号：US20180024132A1
公开(公告)日：2018-01-25
申请号：US15644095
申请日：2017-07-07
发明人： Michael Andrew Kiebish , Niven Rajin Narain , Rangaprasad Sarangarajan , Viatcheslav R. Akmaev , Leonardo Rodrigues , Yezhou Sun , Shiv Srivastava , Albert Dobi
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57434 , A61K31/00 , C07C229/12 , C12Q1/6886 , G01N2021/3155 , G01N2030/027 , G01N2500/10 , G01N2800/60 , G01R33/46
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
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公开(公告)号：US20240230651A1
公开(公告)日：2024-07-11
申请号：US18286075
申请日：2022-04-06
申请人： BPGBIO, INC. , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Windber Research Institute
发明人： Michael Andrew Kiebish , Albert John Kovatich , Punit Shah , Niven Rajin Narain , Rangaprasad Sarangarajan , Guisong Wang , Jeffery A. Hooke , Hai Hu , Jamie Leigh Campbell , Mary L. Cutler , Craig D. Shriver
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57415 , G01N33/6851 , G01N2333/976 , G01N2458/15
摘要： Methods for prognosing the risk of progression in a ER-positive breast cancer (e.g., luminal B 1 breast cancer) subject are provided, such methods including the detection of levels of a variety of biomarkers prognostic of progression. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
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公开(公告)号：US20200018758A1
公开(公告)日：2020-01-16
申请号：US16509808
申请日：2019-07-12
申请人： Berg LLC
IPC分类号： G01N33/574 , C12Q1/6886
摘要： Methods for differentiating between benign prostatic hyperplasia (BPH) and prostate cancer, in a subject, are provided, such methods including the detection of levels of one or more biomarker diagnostic of BPH. The invention also provides a kit for the diagnosis of BPH, without the need for a biopsy.
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公开(公告)号：US10352947B2
公开(公告)日：2019-07-16
申请号：US14025803
申请日：2013-09-12
申请人： Berg LLC
IPC分类号： G01N33/68
摘要： The invention provides methods for the diagnosis and prognosis of cardiovascular disease, and for monitoring of the treatment of cardiovascular disease, including heart failure and cardiomyopathy. The invention further provides methods for identifying an agent for treating cardiomyopathy or heart failure, for identifying a cardiotoxic agent, and for identifying a rescue agent to reduce or prevent drug-induced toxicity, by using one or more biomarkers selelcted from the group consisting of CCDC47, HMOX1, PTX3, PAI1, IL27, IGFBP7, Emmprin, CFL2, EDIL3, NUCB1, PE D18:0-20:3/D18:1-20:2/D16:0-22:3; PE D18:0-22:5/D18:1-22:4; PE D16:1-22:6; PE P18:1-18:1/P18:0-18:2/P16:0-20:2; LPC 20:3; and PC-LI-183-D18:22-22:6, or any of the other biomarkers provided herein. The invention further provides kits for practicing the methods of the invention.
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公开(公告)号：US20230142060A1
公开(公告)日：2023-05-11
申请号：US17863964
申请日：2022-07-13
申请人： Berg LLC
IPC分类号： A61K31/122 , A61P17/02 , A61K39/395 , A61K45/06 , A61K31/513
CPC分类号： A61K31/122 , A61P17/02 , A61K39/395 , A61K45/06 , A61K31/513 , A61K9/06
摘要： The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of a of Coenzyme Q10 (CoQ10) to the subject.
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公开(公告)号：US20230059578A1
公开(公告)日：2023-02-23
申请号：US17714778
申请日：2022-04-06
申请人： Berg LLC , The Henry M. Jackson Foundation for the Advancement ofMilitary Medicine , Windber Research Institute
发明人： Michael Andrew Kiebish , Albert John Kovatich , Punit Shah , Niven Rajin Narain , Rangaprasad Sarangarajan , Guisong Wang , Jeffery A. Hooke , Jamie Leigh Campbell , Mary Lou Cutler , Craig D. Shriver , Hai Hu
IPC分类号： G01N33/574 , C12Q1/6886
摘要： The present invention relates to protein markers for ER-positive-like and ER-negative-like breast cancer. Methods for differentiating ER-positive-like and ER-negative-like breast cancer in a subject having breast cancer are provided, such methods including the detection of levels of a variety of biomarkers for ER-positive-like and ER-negative-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
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10.发明授权公开(公告)号：US11419830B2
公开(公告)日：2022-08-23
申请号：US15981831
申请日：2018-05-16
申请人： Berg LLC
IPC分类号： A61K31/122 , A61P17/02 , A61K39/395 , A61K45/06 , A61K31/513 , A61K9/06 , A61K9/00 , A61Q19/00
摘要： The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of a of Coenzyme Q10 (CoQ10) to the subject.
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