公开(公告)号：US5849522A

公开(公告)日：1998-12-15

申请号：US467143

申请日：1995-06-06

申请人： Bernhard Fleckenstein ,  Walter Schaffner ,  Frank Weber ,  Karoline Dorsch-Hasler ,  Gerhard Jahn ,  Michael Boshart

发明人： Bernhard Fleckenstein ,  Walter Schaffner ,  Frank Weber ,  Karoline Dorsch-Hasler ,  Gerhard Jahn ,  Michael Boshart

IPC分类号： C12N15/09 ,  C12N15/00 ,  C12N15/85 ,  C12P21/02 ,  C07H21/04 ,  C12N15/11 ,  C12N15/67

CPC分类号： C12N15/85 ,  C12N2800/60

摘要： An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.

摘要翻译： 增强子已经位于人巨细胞病毒的主要即时早期基因的上游区域，并且已被分离，其增强剂比来自SV40的活性更强，并且具有广泛的宿主细胞谱。 因此，它适合于其可以结合到结构基因或调节区的上游或下游的真核表达系统。

公开(公告)号：US06218140B1

公开(公告)日：2001-04-17

申请号：US08338213

申请日：1994-11-09

申请人： Bernhard Fleckenstein ,  Walter Schaffner ,  Frank Weber ,  Karoline Dorsch-Häsler ,  Gerhard Jahn ,  Michael Boshart

发明人： Bernhard Fleckenstein ,  Walter Schaffner ,  Frank Weber ,  Karoline Dorsch-Häsler ,  Gerhard Jahn ,  Michael Boshart

IPC分类号： C12P2100

CPC分类号： C12N15/85 ,  C12N2800/60

摘要： An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.

摘要翻译： 增强子已经位于人巨细胞病毒的主要即时早期基因的上游区域，并且已被分离，其增强剂比来自SV40的活性更强，并且具有广泛的宿主细胞谱。 因此，它适合于其可以结合到结构基因或调节区的上游或下游的真核表达系统。