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    Polypeptides encoded by Kaposi sarcoma-associated herpes virus the use thereof in diagnosis and therapy
    2.
    发明授权
    Polypeptides encoded by Kaposi sarcoma-associated herpes virus the use thereof in diagnosis and therapy 失效
    卡波西肉瘤相关疱疹病毒编码的多肽在诊断和治疗中的应用

    公开(公告)号：US06177080B1

    公开(公告)日：2001-01-23

    申请号：US09112248

    申请日：1998-07-08

    申请人： Bernhard Fleckenstein ,  Jens-Christian Albrecht ,  Frank Neipel ,  Dieter Lang

    发明人： Bernhard Fleckenstein ,  Jens-Christian Albrecht ,  Frank Neipel ,  Dieter Lang

    IPC分类号： A61K3912

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/085 ,  C12N2710/16222 ,  C12N2710/16422

    摘要： The invention relates to polypeptides of the Kaposi sarcoma-associated herpes virus which have a part-sequence of at least 10 consecutive amino acids from the sequence Met Ser Ser Thr Gln Ile Arg Thr Glu Ile Pro Val Ala Leu Leu Ile Leu Cys Leu Cys Leu Val Ala Cys His Ala Asn Cys Pro Thr Tyr Arg Ser His Leu Gly Phe Trp Gln Glu Gly Trp Ser Gly Gln Val Tyr Gln Asp Trp Leu Gly Arg Met Asn Cys Ser Tyr Glu Asn Met Thr Ala Leu Glu Ala Val Ser Leu Asn Gly Thr Arg Leu Ala Ala Gly Ser Pro Ser Ser Glu Tyr Pro Asn Val Ser Val Ser Val Glu Asp Thr Ser Ala Ser Gly Ser Gly Glu Asp Ala Ile Asp Glu Ser Gly Ser Gly Glu Glu Glu Arg Pro Val Thr Ser His Val Thr Phe Met Thr Gln Ser Val Gln Ala Thr Thr Glu Leu Thr Asp Ala Leu Ile Ser Ala Phe Ser Gly Val Leu His Val Ser Thr Val Ile Pro Arg Asn Trp Val Asn Arg Arg Cys Val Gly Ile Lys Arg Asn Leu Thr Phe Cys Leu Ile Tyr Arg Ile Ile Phe Ile Trp Gly Thr Ile Gln Asp His Ala Asn Ser Arg Ile Thr Gly Arg Arg Lys Arg Gln Lys and to the use thereof in therapy and diagnosis.

    摘要翻译： 本发明涉及卡波西肉瘤相关疱疹病毒的多肽，其在序列中具有至少10个连续氨基酸的部分序列，并且在治疗和诊断中的用途。

    Human semaphorin L (H-SemaL) and corresponding semaphorins in other species
    6.
    发明授权
    Human semaphorin L (H-SemaL) and corresponding semaphorins in other species 失效
    人类信号素L（H-SemaL）和其他物种中的相应semaphorins

    公开(公告)号：US07339030B2

    公开(公告)日：2008-03-04

    申请号：US10933746

    申请日：2004-09-03

    申请人： Bernhard Fleckenstein ,  Armin Ensser

    发明人： Bernhard Fleckenstein ,  Armin Ensser

    IPC分类号： A61K38/16 ,  C07K14/00

    CPC分类号： C07K14/4703 ,  A61K48/00 ,  C07K2319/02

    摘要： The invention relates to novel semaphorins which are distinguished by a particular domain structure and derivatives thereof, nucleic acids (DNA, RNA, cDNA) which code for these semaphorins, and derivatives thereof, and the use thereof.The present invention relates to semaphorins which have a novel, as yet undisclosed and unexpected domain structure and which possess a biochemical function in the immune system (immunomodulating semaphorins). The novel semaphorins are referred to as type L semaphorins (SemaL). They comprise an N-terminal signal peptide, a characteristic Sema domain and, in the C-terminal region of the protein, an immunoglobulin-like domain and a hydrophobic domain which represents a potential transmembrane domain.

    摘要翻译： 本发明涉及通过特定结构域结构及其衍生物，编码这些信号素的核酸（DNA，RNA，cDNA）及其衍生物及其用途来区分的新的信号素。 本发明涉及具有新颖尚未公开和意想不到的结构域结构并且在免疫系统（免疫调节信号素）中具有生物化学功能的信号素。 新的信号素被称为L型信号素（SemaL）。 它们包括N-末端信号肽，特征Sema结构域，并且在蛋白质的C-末端区域中，代表潜在跨膜结构域的免疫球蛋白样结构域和疏水结构域。

    Selectable vectors for human T cells
    9.
    发明授权
    Selectable vectors for human T cells 失效
    人T细胞可选载体

    公开(公告)号：US6025153A

    公开(公告)日：2000-02-15

    申请号：US946787

    申请日：1992-09-18

    申请人： Bernhard Fleckenstein ,  Ralph Grassmann

    发明人： Bernhard Fleckenstein ,  Ralph Grassmann

    IPC分类号： C12N15/869 ,  C12P21/00 ,  C12N15/64 ,  C12N15/86

    CPC分类号： C12N15/86 ,  C12N2710/16443

    摘要： Selectable Herpesvirus saimiri vectors which have a selection gene inserted into a junction region of the L- and H-DNA are described. Vectors of this type are able persistently to infect human T cells and thus are suitable for the expression of foreign genes in human T cells. An additional advantage is that no infectious virus particles are produced during this.

    摘要翻译： 描述了具有插入到L-和H-DNA的连接区域中的选择基因的可选择的疱疹病毒simiri载体。 这种载体能够持续感染人类T细胞，因此适用于人T细胞中外源基因的表达。 另外的优点是在此期间不产生感染性病毒颗粒。