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    USE OF RGM AND ITS MODULATORS
    2.
    发明申请
    USE OF RGM AND ITS MODULATORS 审中-公开
    RGM及其调制器的使用

    公开(公告)号：US20110112280A1

    公开(公告)日：2011-05-12

    申请号：US12939823

    申请日：2010-11-04

    申请人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Andersen

    发明人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Andersen

    IPC分类号： C07K16/00 ,  C07K14/00 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/465 ,  C07K14/4702 ,  C07K16/28

    摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardiovascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardiovascular system. In addition, the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical compositions for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.

    摘要翻译： 本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途 预防，减轻或治疗与癫痫相关的脊髓动物神经组织的退化或损伤相关的疾病或病症，或与心血管系统的血管生成障碍或病症有关。 此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物 或治疗与血管生成障碍或心血管系统疾病相关的脊椎动物神经组织的退化或损伤相关的疾病或病症。 此外，本发明提供了所述多肽或其功能片段或衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标志物的药物组合物的用途。

    Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
    4.
    发明授权
    Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) 有权
    针对排斥指导分子（RGM）的抗体的治疗用途

    公开(公告)号：US07981420B2

    公开(公告)日：2011-07-19

    申请号：US10451586

    申请日：2001-12-21

    申请人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Anderson

    发明人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Anderson

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/465 ,  C07K14/4702 ,  C07K16/28

    摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardio-vascular system. In addition the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical composition for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.

    摘要翻译： 本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途 预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。 此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物 或治疗与脊髓动物神经组织的变性或损伤相关的疾病或病症，与血管生成障碍或心血管系统的病症有关。 此外，本发明提供了所述多肽或其功能片段或其衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标记的药物组合物的用途。