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19 条记录 (耗时 0.035 秒)

    USE OF RGM AND ITS MODULATORS
    2.
    发明申请
    USE OF RGM AND ITS MODULATORS 审中-公开
    RGM及其调制器的使用

    公开(公告)号：US20110112280A1

    公开(公告)日：2011-05-12

    申请号：US12939823

    申请日：2010-11-04

    申请人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Andersen

    发明人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Andersen

    IPC分类号： C07K16/00 ,  C07K14/00 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/465 ,  C07K14/4702 ,  C07K16/28

    摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardiovascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardiovascular system. In addition, the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical compositions for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.

    摘要翻译： 本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途 预防，减轻或治疗与癫痫相关的脊髓动物神经组织的退化或损伤相关的疾病或病症，或与心血管系统的血管生成障碍或病症有关。 此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物 或治疗与血管生成障碍或心血管系统疾病相关的脊椎动物神经组织的退化或损伤相关的疾病或病症。 此外，本发明提供了所述多肽或其功能片段或衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标志物的药物组合物的用途。

    Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
    4.
    发明授权
    Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) 有权
    针对排斥指导分子（RGM）的抗体的治疗用途

    公开(公告)号：US07981420B2

    公开(公告)日：2011-07-19

    申请号：US10451586

    申请日：2001-12-21

    申请人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Anderson

    发明人： Bernhard K. Mueller ,  Philippe P. Monnier ,  Paolo Macchi ,  Friedrich Bonhoeffer ,  Bernd Stahl ,  Matthias Mann ,  Jens S. Anderson

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/465 ,  C07K14/4702 ,  C07K16/28

    摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardio-vascular system. In addition the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical composition for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.

    摘要翻译： 本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途 预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。 此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物 或治疗与脊髓动物神经组织的变性或损伤相关的疾病或病症，与血管生成障碍或心血管系统的病症有关。 此外，本发明提供了所述多肽或其功能片段或其衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标记的药物组合物的用途。

    Welding head for a looping machine
    7.
    发明授权
    Welding head for a looping machine 有权
    焊接头用于循环机

    公开(公告)号：US06405917B1

    公开(公告)日：2002-06-18

    申请号：US09635855

    申请日：2000-08-11

    申请人： Matthias Mann

    发明人： Matthias Mann

    IPC分类号： B23K3704

    CPC分类号： B65B13/32 ,  B23K37/04

    摘要： A welding head for looping machine is provided with a strap guide (7) for passing the looping strap (5) through the welding head (1), a strap fixing element (14) for holding the lapping strap sections (3, 4) which are to be welded together, a welding set (17) for melting the looping strap sections (3, 4) which are to be welded together, a pressing arrangement for joining the melted strap sections (3, 4) which are to be welded together, and a mechanically operating ejector (30) which is integrated in the welding head (1) for lifting the welded looping strap (5) out of the welding head (1).

    摘要翻译： 环绕机的焊接头设置有用于使环形带（5）穿过焊接头（1）的带引导件（7），用于保持研磨带部分（3,4）的带固定元件（14），其中， 要焊接在一起的焊接组件（17），用于熔化待焊接在一起的环形带部分（3,4）的焊接组件（17），用于接合待焊接在一起的熔化的带部分（3,4）的按压装置 以及集成在焊接头（1）中用于将焊接的环形带（5）从焊接头（1）中提出的机械操作的喷射器（30）。

    Method for determining molecular weight using multiply charged ions
    9.
    发明授权
    Method for determining molecular weight using multiply charged ions 失效
    使用多电荷离子测定分子量的方法

    公开(公告)号：US5581080A

    公开(公告)日：1996-12-03

    申请号：US309852

    申请日：1994-09-21

    申请人： John B. Fenn ,  Chin-Kai Meng ,  Matthias Mann

    发明人： John B. Fenn ,  Chin-Kai Meng ,  Matthias Mann

    IPC分类号： B01D59/44 ,  H01J49/04 ,  H01J49/00

    CPC分类号： H01J49/165 ,  B01D59/44 ,  H01J49/427

    摘要： A production of mass spectra which contain a multiplicity of peaks. The component ions of these peaks, which are multiply charged, are formed by dispersing a solution containing an analyte into a bath gas as highly charged droplets. The analyte is generally a compound of high molecular weight and is of biochemical interest. The methods calculate the molecular weight of the analyte from the measured mass values of the highly charged ions.

    摘要翻译： 产生含有多个峰的质谱。 通过将含有分析物的溶液分散到作为高电荷液滴的浴气中形成这些峰的成分离子，其是多重带电的。 分析物通常是高分子量的化合物，具有生物化学意义。 该方法从高电荷离子的测量质量值计算分析物的分子量。