公开(公告)号：US20060246560A1

公开(公告)日：2006-11-02

申请号：US11334713

申请日：2006-01-17

申请人： Beth Fatland-Bloom ,  Gyan Rai ,  P. Rayapati ,  Nyerhovwo Tonukari

发明人： Beth Fatland-Bloom ,  Gyan Rai ,  P. Rayapati ,  Nyerhovwo Tonukari

IPC分类号： C12P7/56 ,  C12P7/46 ,  C12N1/21 ,  C12N1/18 ,  C12N15/74 ,  C12P7/20

CPC分类号： C12P7/56 ,  C12N9/93 ,  C12P7/20 ,  C12P7/46

摘要： Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also are provided.

公开(公告)号：US20090042264A1

公开(公告)日：2009-02-12

申请号：US12195869

申请日：2008-08-21

申请人： Beth Fatland-Bloom ,  Gyan Rai ,  P. John Rayapati ,  Nyerhovwo John Tonukari

发明人： Beth Fatland-Bloom ,  Gyan Rai ,  P. John Rayapati ,  Nyerhovwo John Tonukari

IPC分类号： C12P7/56 ,  C12N15/11 ,  C12N15/00 ,  C12P7/20 ,  C12P7/46 ,  C12N1/20 ,  C12N1/19

CPC分类号： C12P7/56 ,  C12N9/93 ,  C12P7/20 ,  C12P7/46

摘要： Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also are provided.

摘要翻译： 提供了可用于调节编码通过代谢途径转化碳通量的基因的基因组序列和遗传构建体，所述代谢途径导致宿主细胞例如米曲霉细胞中的乳酸或富马酸盐的产生。 还提供了操作细胞中碳通量的方法。

公开(公告)号：US07435168B2

公开(公告)日：2008-10-14

申请号：US11334713

申请日：2006-01-17

申请人： Beth Fatland-Bloom ,  Gyan Rai ,  P. John Rayapati ,  Nyerhovwo John Tonukari

发明人： Beth Fatland-Bloom ,  Gyan Rai ,  P. John Rayapati ,  Nyerhovwo John Tonukari

IPC分类号： C12P21/06 ,  C12P19/34 ,  C12P7/56 ,  C12P7/46 ,  C12N1/20 ,  C12N1/00 ,  C12N15/74

CPC分类号： C12P7/56 ,  C12N9/93 ,  C12P7/20 ,  C12P7/46

摘要： Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also are provided.

摘要翻译： 提供了可用于调节编码通过代谢途径转化碳通量的基因的基因组序列和遗传构建体，所述代谢途径导致宿主细胞例如米曲霉细胞中的乳酸或富马酸盐的产生。 还提供了操作细胞中碳通量的方法。

公开(公告)号：US07566563B2

公开(公告)日：2009-07-28

申请号：US12195869

申请日：2008-08-21

申请人： Beth Fatland-Bloom ,  Gyan Rai ,  P. John Rayapati ,  Nyerhovwo John Tonukari

发明人： Beth Fatland-Bloom ,  Gyan Rai ,  P. John Rayapati ,  Nyerhovwo John Tonukari

IPC分类号： C12N1/20 ,  C12P19/34 ,  C12P21/06 ,  C12P7/56 ,  C12P7/48 ,  C12P7/20 ,  C07H21/04

CPC分类号： C12P7/56 ,  C12N9/93 ,  C12P7/20 ,  C12P7/46

摘要： Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also are provided.

摘要翻译： 提供了可用于调节编码通过代谢途径转化碳通量的基因的基因组序列和遗传构建体，所述代谢途径导致宿主细胞例如米曲霉细胞中的乳酸或富马酸盐的产生。 还提供了操作细胞中碳通量的方法。