公开(公告)号：US20190240319A1

公开(公告)日：2019-08-08

申请号：US16385438

申请日：2019-04-16

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Children's Medical Center Corporation

发明人： Stephen C. HARRISON ,  Bing CHEN ,  Dan H. BAROUCH ,  Joseph P. NKOLOLA ,  Michael Scott SEAMAN

IPC分类号： A61K39/21 ,  C12N7/00 ,  A61K39/12 ,  C07K14/005

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16051 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

摘要： Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.

公开(公告)号：US20200323976A1

公开(公告)日：2020-10-15

申请号：US16858808

申请日：2020-04-27

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Children's Medical Center Corporation

发明人： Stephen C. HARRISON ,  Bing CHEN ,  Dan BAROUCH ,  Joseph P. NKOLOLA ,  Michael Scott SEAMAN

IPC分类号： A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  C12N7/00

摘要： Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.

公开(公告)号：US20200023056A1

公开(公告)日：2020-01-23

申请号：US16579025

申请日：2019-09-23

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Children's Medical Center Corporation

发明人： Stephen C. HARRISON ,  Bing CHEN ,  Dan BAROUCH ,  Joseph P. NKOLOLA ,  Michael Scott SEAMAN

IPC分类号： A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  C12N7/00

摘要： Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.

公开(公告)号：US20180207259A1

公开(公告)日：2018-07-26

申请号：US15919834

申请日：2018-03-13

申请人： Beth Israel Deaconess Medical Center ,  Children's Medical Center Corporation

发明人： Stephen C. HARRISON ,  Bing CHEN ,  Dan H. BAROUCH ,  Joseph P. NKOLOLA ,  Michael Scott SEAMAN

IPC分类号： A61K39/21 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16051 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

摘要： Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.

公开(公告)号：US20170290907A1

公开(公告)日：2017-10-12

申请号：US15596312

申请日：2017-05-16

申请人： Beth Israel Deaconess Medical Center ,  Children's Medical Center Corporation

发明人： Stephen C. HARRISON ,  Bing CHEN ,  Dan H. BAROUCH ,  Joseph P. NKOLOA ,  Michael Scott SEAMAN

IPC分类号： A61K39/21 ,  C12N7/00 ,  C07K14/005

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16051 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

摘要： Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.