公开(公告)号：US06384915B1

公开(公告)日：2002-05-07

申请号：US09050570

申请日：1998-03-30

申请人： Matthew Everett ,  Billy W. Colston ,  Luiz B. Da Silva ,  Dennis Matthews

发明人： Matthew Everett ,  Billy W. Colston ,  Luiz B. Da Silva ,  Dennis Matthews

IPC分类号： G01N1502

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/0084

摘要： A guidance and viewing system based on multiplexed optical coherence domain reflectometry is incorporated into a catheter, endoscope, or other medical device to measure the location, thickness, and structure of the arterial walls or other intra-cavity regions at discrete points on the medical device during minimally invasive medical procedures. The information will be used both to guide the device through the body and to evaluate the tissue through which the device is being passed. Multiple optical fibers are situated along the circumference of the device. Light from the distal end of each fiber is directed onto the interior cavity walls via small diameter optics (such as gradient index lenses and mirrored corner cubes). Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers and multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The system may also be implemented in a nonmedical inspection device.

摘要翻译： 基于复合光学相干畴反射测量的引导和观察系统被并入到导管，内窥镜或其他医疗装置中，以测量医疗装置上的离散点处的动脉壁或其它腔内区域的位置，厚度和结构 在微创医疗程序中。 该信息将用于引导装置穿过身体并评估装置通过的组织。 多个光纤沿着设备的圆周设置。 来自每根纤维的远端的光通过小直径光学器件（例如梯度折射率透镜和镜像角立方体）被引导到内腔壁上。 可以包括前视和侧视纤维。 然后从空腔壁反射或散射的光被纤维收集，并在近端多路复用到光学低相干反射计的样品臂。 该系统还可以在非医疗检查装置中实现。

公开(公告)号：US06175669B1

公开(公告)日：2001-01-16

申请号：US09050571

申请日：1998-03-30

申请人： Billy W. Colston ,  Matthew Everett ,  Luiz B. Da Silva ,  Dennis Matthews

发明人： Billy W. Colston ,  Matthew Everett ,  Luiz B. Da Silva ,  Dennis Matthews

IPC分类号： G02B600

CPC分类号： A61B5/6852 ,  A61B1/00177 ,  A61B1/00181 ,  A61B5/0066 ,  A61B5/0084

摘要： A guidewire with optical sensing capabilities is based on a multiplexed optical coherence domain reflectometer (OCDR), which allows it to sense location, thickness, and structure of the arterial walls or other intra-cavity regions as it travels through the body during minimally invasive medical procedures. This information will be used both to direct the guidewire through the body by detecting vascular junctions and to evaluate the nearby tissue. The guidewire contains multiple optical fibers which couple light from the proximal to distal end. Light from the fibers at the distal end of the guidewire is directed onto interior cavity walls via small diameter optics such as gradient index lenses and mirrored corner cubes. Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers, which are multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The guidewire can also be used in nonmedical applications.

摘要翻译： 具有光学感测能力的导丝基于多路复用光学相干域反射计（OCDR），其允许其在微创医疗中穿过身体时感测动脉壁或其他腔内区域的位置，厚度和结构 程序。 该信息将用于通过检测血管结点引导导线穿过身体并评估附近的组织。 导丝包含多个光纤，其将光从近端耦合到远端。 来自导线远端的纤维的光通过诸如梯度折射率透镜和镜像角立方体的小直径光学器件引导到内腔壁上。 可以包括前视和侧视纤维。 然后从空腔壁反射或散射的光被纤维收集，纤维在近端被多路复用到光学低相干反射计的样品臂。 导丝也可用于非医疗应用。

公开(公告)号：US5912945A

公开(公告)日：1999-06-15

申请号：US880850

申请日：1997-06-23

申请人： Luiz B. Da Silva ,  Dennis L. Matthews ,  Joseph P. Fitch ,  Matthew J. Everett ,  Billy W. Colston ,  Gary F. Stone

发明人： Luiz B. Da Silva ,  Dennis L. Matthews ,  Joseph P. Fitch ,  Matthew J. Everett ,  Billy W. Colston ,  Gary F. Stone

IPC分类号： G01T1/161 ,  A61B17/00

CPC分类号： G01T1/161

摘要： An apparatus and method for determining the orientation of a device with respect to an x-ray source. In one embodiment, the present invention is coupled to a medical device in order to determine the rotational orientation of the medical device with respect to the x-ray source. In such an embodiment, the present invention is comprised of a scintillator portion which is adapted to emit photons upon the absorption of x-rays emitted from the x-ray source. An x-ray blocking portion is coupled to the scintillator portion. The x-ray blocking portion is disposed so as to vary the quantity of x-rays which penetrate the scintillator portion based upon the particular rotational orientation of the medical device with respect to the x-ray source. A photon transport mechanism is also coupled to the scintillator portion. The photon transport mechanism is adapted to pass the photons emitted from the scintillator portion to an electronics portion. By analyzing the quantity of the photons, the electronics portion determines the rotational orientation of the medical device with respect to the x-ray source.

摘要翻译： 一种用于确定装置相对于x射线源的取向的装置和方法。 在一个实施例中，本发明被耦合到医疗装置，以便确定医疗装置相对于x射线源的旋转取向。 在这样的实施例中，本发明包括闪烁体部分，其适于在吸收从X射线源发射的x射线时发射光子。 X射线阻挡部分耦合到闪烁体部分。 X射线阻挡部分被设置成基于医疗装置相对于x射线源的特定旋转取向来改变穿透闪烁体部分的X射线的量。 光子传输机构也耦合到闪烁体部分。 光子传输机构适于将从闪烁器部分发射的光子传递到电子部分。 通过分析光子的数量，电子部分确定医疗装置相对于x射线源的旋转取向。

公开(公告)号：US06905885B2

公开(公告)日：2005-06-14

申请号：US09880515

申请日：2001-06-12

申请人： Billy W. Colston ,  Matthew Everett ,  Fred P. Milanovich ,  Steve B. Brown ,  Kodumudi Vendateswaran ,  Jonathan N. Simon

发明人： Billy W. Colston ,  Matthew Everett ,  Fred P. Milanovich ,  Steve B. Brown ,  Kodumudi Vendateswaran ,  Jonathan N. Simon

IPC分类号： G01N33/543 ,  G01N33/53

CPC分类号： G01N33/54313

摘要： A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

摘要翻译： 便携式病原体检测系统，实现了生物样品中靶标的现场多重检测。 该系统包括：微珠特异性试剂，孵育/混合室，一次性微珠捕获底物和光学测量和解码装置。 该系统的基础是高度灵活的液体阵列，其利用光学编码的微珠作为生物测定的模板。 目标生物样品被光学标记并捕获在微珠上，微珠又依次在有序阵列或无序阵列一次性捕获基底上捕获，然后光学读取。

公开(公告)号：US06466713B2

公开(公告)日：2002-10-15

申请号：US09883513

申请日：2001-06-18

申请人： Matthew J. Everett ,  Billy W. Colston ,  Dale L. James ,  Steve Brown ,  Luiz Da Silva

发明人： Matthew J. Everett ,  Billy W. Colston ,  Dale L. James ,  Steve Brown ,  Luiz Da Silva

IPC分类号： G02B626

CPC分类号： G02B6/241 ,  A61B5/0066 ,  A61B5/0084 ,  G02B6/262

摘要： The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle &thgr;. The planar surface is coated with a reflective material so that light traveling axially through the fiber is reflected transverse to the fiber's axial centerline, and is emitted laterally through the side of the fiber. Alternatively, the planar surface can be left uncoated. The polishing angle &thgr; must be no greater than 39° or must be at least 51°. The emitted light is reflected from adjacent biological tissue, collected by the head, and then processed to provide real-time images of the tissue. The method for forming the planar surface includes shearing the end of the optical fiber and applying the reflective material before removing the buffer that circumscribes the cladding and the core.