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公开(公告)号：US5912945A
公开(公告)日：1999-06-15
申请号：US880850
申请日：1997-06-23
申请人： Luiz B. Da Silva , Dennis L. Matthews , Joseph P. Fitch , Matthew J. Everett , Billy W. Colston , Gary F. Stone
发明人： Luiz B. Da Silva , Dennis L. Matthews , Joseph P. Fitch , Matthew J. Everett , Billy W. Colston , Gary F. Stone
CPC分类号： G01T1/161
摘要： An apparatus and method for determining the orientation of a device with respect to an x-ray source. In one embodiment, the present invention is coupled to a medical device in order to determine the rotational orientation of the medical device with respect to the x-ray source. In such an embodiment, the present invention is comprised of a scintillator portion which is adapted to emit photons upon the absorption of x-rays emitted from the x-ray source. An x-ray blocking portion is coupled to the scintillator portion. The x-ray blocking portion is disposed so as to vary the quantity of x-rays which penetrate the scintillator portion based upon the particular rotational orientation of the medical device with respect to the x-ray source. A photon transport mechanism is also coupled to the scintillator portion. The photon transport mechanism is adapted to pass the photons emitted from the scintillator portion to an electronics portion. By analyzing the quantity of the photons, the electronics portion determines the rotational orientation of the medical device with respect to the x-ray source.
摘要翻译： 一种用于确定装置相对于x射线源的取向的装置和方法。 在一个实施例中，本发明被耦合到医疗装置，以便确定医疗装置相对于x射线源的旋转取向。 在这样的实施例中，本发明包括闪烁体部分，其适于在吸收从X射线源发射的x射线时发射光子。 X射线阻挡部分耦合到闪烁体部分。 X射线阻挡部分被设置成基于医疗装置相对于x射线源的特定旋转取向来改变穿透闪烁体部分的X射线的量。 光子传输机构也耦合到闪烁体部分。 光子传输机构适于将从闪烁器部分发射的光子传递到电子部分。 通过分析光子的数量，电子部分确定医疗装置相对于x射线源的旋转取向。
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公开(公告)号：US06522407B2
公开(公告)日：2003-02-18
申请号：US10100824
申请日：2002-03-18
申请人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva , Daniel Fried
发明人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva , Daniel Fried
IPC分类号： G01J400
CPC分类号： A61B5/0088 , A61B5/0066 , A61B5/0073 , G01B9/02091 , G01B2290/70 , G01N21/4795
摘要： A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.
摘要翻译： 偏振敏感光学成像系统用于检测牙组织中极化的变化，以帮助牙科疾病如龋齿的诊断。 通过用偏振光照射牙组织并测量背向散射光的偏振状态来测量去极化度。 使用光学偏振成像技术分析该反射光的偏振状态。 体内使用手持光纤牙科探针将入射光束引导到牙齿组织并收集反射光。 为了提供牙科组织的深度分辨表征，偏振诊断可以被并入到光学相干畴反射测量和光学相干断层扫描（OCDR / OCT）系统中，其能够识别与釉质或骨的脱矿质相关的地下去极化位点。
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公开(公告)号：US06179611B2
公开(公告)日：2001-01-30
申请号：US09315000
申请日：1999-05-19
IPC分类号： A61C100
CPC分类号： A61B5/0088 , A61B5/0066 , G01B9/02027 , G01B9/0205 , G01B9/02091 , G01N21/4795
摘要： A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at the point where the tip of the dental explorer touches the tissue. This system provides information on the internal structure of the dental tissue, which is then used to detect caries and periodontal disease. A series of profiles of optical scattering or tissue microstructure are generated by moving the explorer across the tooth or other tissue. The profiles are combined to form a cross-sectional, or optical coherence tomography (OCT), image.
摘要翻译： 具有光学相干畴反射测量（OCDR）感测能力的手持式基于光纤的牙齿设备提供了在牙科探险者的尖端接触组织的点处的组织中的深度的函数的光学散射的轮廓。 该系统提供关于牙科组织的内部结构的信息，然后用于检测龋齿和牙周病。 通过移动探查器穿过牙齿或其他组织，产生一系列光学散射或组织微结构。 轮廓组合形成横截面或光学相干断层扫描（OCT）图像。
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公开(公告)号：US06384915B1
公开(公告)日：2002-05-07
申请号：US09050570
申请日：1998-03-30
IPC分类号： G01N1502
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0084
摘要： A guidance and viewing system based on multiplexed optical coherence domain reflectometry is incorporated into a catheter, endoscope, or other medical device to measure the location, thickness, and structure of the arterial walls or other intra-cavity regions at discrete points on the medical device during minimally invasive medical procedures. The information will be used both to guide the device through the body and to evaluate the tissue through which the device is being passed. Multiple optical fibers are situated along the circumference of the device. Light from the distal end of each fiber is directed onto the interior cavity walls via small diameter optics (such as gradient index lenses and mirrored corner cubes). Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers and multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The system may also be implemented in a nonmedical inspection device.
摘要翻译： 基于复合光学相干畴反射测量的引导和观察系统被并入到导管，内窥镜或其他医疗装置中，以测量医疗装置上的离散点处的动脉壁或其它腔内区域的位置，厚度和结构 在微创医疗程序中。 该信息将用于引导装置穿过身体并评估装置通过的组织。 多个光纤沿着设备的圆周设置。 来自每根纤维的远端的光通过小直径光学器件（例如梯度折射率透镜和镜像角立方体）被引导到内腔壁上。 可以包括前视和侧视纤维。 然后从空腔壁反射或散射的光被纤维收集，并在近端多路复用到光学低相干反射计的样品臂。 该系统还可以在非医疗检查装置中实现。
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公开(公告)号：US06175669B1
公开(公告)日：2001-01-16
申请号：US09050571
申请日：1998-03-30
IPC分类号： G02B600
CPC分类号： A61B5/6852 , A61B1/00177 , A61B1/00181 , A61B5/0066 , A61B5/0084
摘要： A guidewire with optical sensing capabilities is based on a multiplexed optical coherence domain reflectometer (OCDR), which allows it to sense location, thickness, and structure of the arterial walls or other intra-cavity regions as it travels through the body during minimally invasive medical procedures. This information will be used both to direct the guidewire through the body by detecting vascular junctions and to evaluate the nearby tissue. The guidewire contains multiple optical fibers which couple light from the proximal to distal end. Light from the fibers at the distal end of the guidewire is directed onto interior cavity walls via small diameter optics such as gradient index lenses and mirrored corner cubes. Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers, which are multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The guidewire can also be used in nonmedical applications.
摘要翻译： 具有光学感测能力的导丝基于多路复用光学相干域反射计（OCDR），其允许其在微创医疗中穿过身体时感测动脉壁或其他腔内区域的位置，厚度和结构 程序。 该信息将用于通过检测血管结点引导导线穿过身体并评估附近的组织。 导丝包含多个光纤，其将光从近端耦合到远端。 来自导线远端的纤维的光通过诸如梯度折射率透镜和镜像角立方体的小直径光学器件引导到内腔壁上。 可以包括前视和侧视纤维。 然后从空腔壁反射或散射的光被纤维收集，纤维在近端被多路复用到光学低相干反射计的样品臂。 导丝也可用于非医疗应用。
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公开(公告)号：US5986234A
公开(公告)日：1999-11-16
申请号：US829519
申请日：1997-03-28
申请人： Dennis L. Matthews , Peter M. Celliers , Lloyd Hackel , Luiz B. Da Silva , C. Brent Dane , Stanley Mrowka
发明人： Dennis L. Matthews , Peter M. Celliers , Lloyd Hackel , Luiz B. Da Silva , C. Brent Dane , Stanley Mrowka
CPC分类号： B23K26/032 , B08B7/0042 , B23K26/066 , B23K26/0884 , B23K26/142 , B23K26/1476
摘要： A compact laser system that removes surface coatings (such as paint, dirt, etc.) at a removal rate as high as 1000 ft.sup.2 /hr or more without damaging the surface. A high repetition rate laser with multiple amplification passes propagating through at least one optical amplifier is used, along with a delivery system consisting of a telescoping and articulating tube which also contains an evacuation system for simultaneously sweeping up the debris produced in the process. The amplified beam can be converted to an output beam by passively switching the polarization of at least one amplified beam. The system also has a personal safety system which protects against accidental exposures.
摘要翻译： 一种紧凑的激光系统，可以以高达1000 ft2 / hr或更高的去除率去除表面涂层（如油漆，污垢等），而不会损坏表面。 使用通过至少一个光学放大器传播的具有多次放大的高重复率激光，以及包括伸缩和铰接管的输送系统，该输送系统还包含用于同时扫掠在该过程中产生的碎片的抽空系统。 放大的光束可以通过被动地切换至少一个放大的光束的偏振而被转换成输出光束。 该系统还具有防止意外暴露的个人安全系统。
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7.发明授权Ultrashort pulse high repetition rate laser system for biological tissue processing 失效超短脉冲高重复率激光系统用于材料加工
公开(公告)号：US5720894A
公开(公告)日：1998-02-24
申请号：US584522
申请日：1996-01-11
申请人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
发明人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
IPC分类号： A61B18/20 , A61B18/26 , A61C3/02 , A61N5/06 , B23K26/03 , B23K26/06 , B23K26/18 , B23K26/36 , B23K26/40 , C06B21/00 , B44C1/22
CPC分类号： B23K26/0665 , A61B18/20 , A61B18/26 , A61C1/0046 , B23K26/032 , B23K26/0624 , B23K26/0643 , B23K26/0648 , B23K26/18 , B23K26/40 , B23K26/402 , C06B21/0033 , A61B2018/00636 , B23K2203/05 , B23K2203/10 , B23K2203/30
摘要： A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.
摘要翻译： 公开了使用以高脉冲重复率操作的超短脉冲持续时间激光系统来快速，有效，精确和无损伤的生物组织去除的方法和装置。 每个激光脉冲的持续时间约为1fs至小于50ps，使得能量沉积位于较小的深度并发生在显着的水动力运动和热传导之间，导致附带损伤。 每个脉冲去除的材料的深度约为1微米，并且与该消融方法相关的最小的热和机械效应允许在10至超过1000赫兹的区域中的高重复率操作，这进而达到 高材料去除率。 每个消融体积的组织的输入激光能量很小，消融材料所需的能量密度随着脉冲宽度的减小而减小。 消融阈值和消融率只是弱取决于组织类型和条件，允许在各种生物组织去除应用中使用的最大灵活性。 在一个实施例中公开了使用啁啾脉冲放大钛掺杂蓝宝石激光器作为源。
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公开(公告)号：US06875207B2
公开(公告)日：2005-04-05
申请号：US10427611
申请日：2003-04-30
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译： 一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。 该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。 吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4） 在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。 有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。
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公开(公告)号：US06638238B1
公开(公告)日：2003-10-28
申请号：US09458134
申请日：1999-12-09
IPC分类号： A61B1720
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译： 一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。 该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。 吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4） 在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。 有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。
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公开(公告)号：US07494492B2
公开(公告)日：2009-02-24
申请号：US11216595
申请日：2005-08-30
申请人： Luiz B. Da Silva , George Choi
发明人： Luiz B. Da Silva , George Choi
IPC分类号： A61B18/08
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761
摘要： A compact hand held device is provided that can be safely used by those suffering from acne, blemished skin or fine wrinkles. The hand held device includes an on/off switch and a button that pulses the device when it is placed on the target site. A battery within the device powers a circuit board and drives a short pulse of current through a heating element, which heats up to approximately 300° C. in less than 0.1 sec. Thermal conduction transfers the heat to the skin and causes a biological response that accelerates acne clearing, treats blemished skin or fine wrinkles. The total heat transferred is low enough to prevent burns. Application of acne treatment creams and gels further accelerates treatment
摘要翻译： 提供了一个紧凑的手持装置，可以被那些患有痤疮，瑕疵的皮肤或细皱纹的人安全使用。 手持设备包括一个开/关开关和一个按钮，当设备放置在目标站点上时，该按钮将脉冲。 设备内的电池为电路板供电，并通过加热元件驱动短脉冲电流，加热元件在小于0.1秒内加热至约300°C。 热传导将热量转移到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤或细皱纹的生物反应。 传热的总热量足够低以防止灼伤。 痤疮治疗霜和凝胶的应用进一步加速治疗
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