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    HGF beta chain variants
    8.
    发明授权
    HGF beta chain variants 失效
    HGFβ链变体

    公开(公告)号：US07737115B2

    公开(公告)日：2010-06-15

    申请号：US11406067

    申请日：2006-04-17

    申请人： Daniel K. Kirchhofer ,  Robert A. Lazarus ,  Christian Wiesmann

    发明人： Daniel K. Kirchhofer ,  Robert A. Lazarus ,  Christian Wiesmann

    IPC分类号： A61K38/18

    CPC分类号： C07K14/4753

    摘要： The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.

    摘要翻译： 本发明提供HGF / Met调节剂，其包含在影响HGF功能的区域中具有突变的HGF，以及靶向所述区域的拮抗剂。 本发明还提供鉴定，制备和使用这些调节剂的方法。

    Polypeptides that inhibit human serum-induced cleavage of hepatocyte growth factor
    9.
    发明授权
    Polypeptides that inhibit human serum-induced cleavage of hepatocyte growth factor 有权
    抑制人血清诱导的肝细胞生长因子切割的多肽

    公开(公告)号：US06800604B2

    公开(公告)日：2004-10-05

    申请号：US09742201

    申请日：2000-12-19

    申请人： Austin L. Gurney ,  Daniel K. Kirchhofer ,  William I. Wood

    发明人： Austin L. Gurney ,  Daniel K. Kirchhofer ,  William I. Wood

    IPC分类号： C07K1400

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/6893 ,  G01N2800/164 ,  G01N2800/32 ,  G01N2800/325

    摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cell comprising those nucleic acid sequences, chimerie polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。