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公开(公告)号：US07470798B2
公开(公告)日：2008-12-30
申请号：US10941121
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
IPC分类号： C07D309/00
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： 7,8-Bicyclic-chroman derivatives of Formula I: wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 7,8-式I的双环 - 苯并二氢吡喃衍生物：其中取代基如说明书或其药学上可接受的盐所定义。 它们可用于治疗炎性疾病，神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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公开(公告)号：US20050065149A1
公开(公告)日：2005-03-24
申请号：US10941121
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Jian Chen , Xianming Jin , Jiangao Song , Wei Zhang
IPC分类号： A61K31/353 , A61K31/675 , A61K31/7048 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12 , A61K31/538 , A61K31/382
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： 7,8-Bicyclic-chroman derivatives of Formula I: wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 7,8-式I的双环 - 苯并二氢吡喃衍生物：其中取代基如说明书或其药学上可接受的盐所定义。 它们可用于治疗炎性疾病，神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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公开(公告)号：US07514461B2
公开(公告)日：2009-04-07
申请号：US10941125
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij M. Elizarov , Xianming Jin , Xianfeng Li , Donald R. James , Jiangao Song , Jian Chen , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij M. Elizarov , Xianming Jin , Xianfeng Li , Donald R. James , Jiangao Song , Jian Chen , Wei Zhang
IPC分类号： A61K31/355 , A61K31/427 , A61K31/4152 , C07D311/72 , C07D405/06 , C07D417/06
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 本发明涉及式I的新型色满衍生物，立体异构体和药学上可接受的盐，其中取代基如说明书中所定义。 它们可用于治疗由脂氧合酶介导的疾病，例如免疫疾病，呼吸系统疾病和心血管疾病，以及治疗神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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公开(公告)号：US20050065150A1
公开(公告)日：2005-03-24
申请号：US10941125
申请日：2004-09-15
申请人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij Elizarov , Xianming Jin , Xianfeng Li , Donald James , Jiangao Song , Jian Chen , Wei Zhang
发明人： Bing Wang , Gail Walkinshaw , Sekhar Boddupalli , Arkadij Elizarov , Xianming Jin , Xianfeng Li , Donald James , Jiangao Song , Jian Chen , Wei Zhang
IPC分类号： A61K31/353 , A61K31/675 , A61K31/7048 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12 , A61K31/382 , A61K31/538
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357 , A61K31/496 , A61K31/675 , A61K31/7048 , C07D295/096 , C07D311/58 , C07D311/70 , C07D311/74 , C07D311/94 , C07D319/08 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/06 , C07D417/12
摘要： The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
摘要翻译： 本发明涉及式I的新型色满衍生物，立体异构体和药学上可接受的盐，其中取代基如说明书中所定义。 它们可用于治疗由脂氧合酶介导的疾病，例如免疫疾病，呼吸系统疾病和心血管疾病，以及治疗神经变性疾病和/或线粒体疾病。 它们也可用于制备用于治疗这些病症的药物制剂。
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公开(公告)号：US09763937B2
公开(公告)日：2017-09-19
申请号：US14964057
申请日：2015-12-09
申请人： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
发明人： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC分类号： C07D241/02 , A61K31/4965 , A61K31/497 , A61K31/4433 , A61K31/44 , A61K31/4436 , A61K31/5355
CPC分类号： A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要： The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号：US20110306625A1
公开(公告)日：2011-12-15
申请号：US12870130
申请日：2010-08-27
申请人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号： A61K31/506 , A61P25/24 , A61P1/08 , C07D401/04 , A61P35/00
CPC分类号： C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号：US20130296318A1
公开(公告)日：2013-11-07
申请号：US13931111
申请日：2013-06-28
申请人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , A61K45/06 , A61K31/506
CPC分类号： C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号：US20130324530A1
公开(公告)日：2013-12-05
申请号：US13885640
申请日：2011-11-17
申请人： William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric J. Martin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric J. Martin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： C07D213/74 , C07D401/14 , C07D409/14 , C07D405/14
CPC分类号： C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。 还提供含有这些化合物的药物组合物和使用这些化合物和组合物治疗由CDK9介导的疾病或病症的方法。
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公开(公告)号：US08501758B2
公开(公告)日：2013-08-06
申请号：US12870130
申请日：2010-08-27
申请人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号： A01N43/54
CPC分类号： C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及B-Raf异常激活的疾病或病症。
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公开(公告)号：US20110130380A1
公开(公告)日：2011-06-02
申请号：US12874389
申请日：2010-09-02
申请人： Paul A. Barsanti , Cheng Hu , Xianming Jin , Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton
发明人： Paul A. Barsanti , Cheng Hu , Xianming Jin , Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton
IPC分类号： A61K31/444 , C07D401/14 , A61K31/4545 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/5377 , A61K31/553 , A61K31/55 , A61P29/00 , A61P37/06 , A61P19/08 , A61P3/00 , A61P25/28 , A61P35/00 , A61P9/00 , A61P11/06 , A61P31/12
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 还提供了使用式I化合物治疗由CDK抑制剂介导的疾病或病症的方法。
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