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公开(公告)号:US20130324530A1
公开(公告)日:2013-12-05
申请号:US13885640
申请日:2011-11-17
申请人: William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric J. Martin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人: William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric J. Martin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号: C07D213/74 , C07D401/14 , C07D409/14 , C07D405/14
CPC分类号: C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.
摘要翻译: 本发明提供式(I)化合物及其药学上可接受的盐,对映体,立体异构体,旋转异构体,互变异构体,非对映体或其外消旋物。 还提供含有这些化合物的药物组合物和使用这些化合物和组合物治疗由CDK9介导的疾病或病症的方法。
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公开(公告)号:US08693465B2
公开(公告)日:2014-04-08
申请号:US13398276
申请日:2012-02-16
IPC分类号: H04L12/56
CPC分类号: H04L41/12 , H04L41/0803 , H04L41/0806 , H04L41/082 , H04L41/0886 , H04L41/5054 , H04L61/2015
摘要: A method performed by a device adapted for communication over a network includes establishing a presence on the network, obtaining default configuration information for the device via the network, the default configuration information identifying a service on the network, receiving a request for validation information from the service, providing the validation information to the service, the service generating device-specific information in response to the validation information, and obtaining the device-specific information.
摘要翻译: 由适于通过网络进行通信的设备执行的方法包括在网络上建立存在,经由网络获取设备的默认配置信息,标识网络上的服务的默认配置信息,从所述网络接收对验证信息的请求 服务,向服务提供验证信息,响应于验证信息产生设备特定信息的服务,以及获得设备特定信息。
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公开(公告)号:US08689345B1
公开(公告)日:2014-04-01
申请号:US13278058
申请日:2011-10-20
IPC分类号: G06F7/04
CPC分类号: G06F21/33 , G06F21/00 , G06F21/31 , G06F2221/2105 , H04L63/08 , H04L63/12 , H04L63/168
摘要: Cross Site Request Forgery (CSRF) and other types of fraudulent submission in an electronic environment can be mitigated using state information that typically is already maintained for various users. Each submission requiring authentication includes a state identifier (ID). The state ID is compared to corresponding a state ID submitted in a relatively secure format, such as in a secure token or cookie. If the state ID matches a state ID in the secure token received from the user, and the state ID is valid, the submission is processed. Otherwise an interstitial page, including the state ID and a secure token, is generated to prompt the user to confirm the submission. A subsequent confirmation submission will contain the proper state ID and the new cookie, and can be processed. If no confirmation is received from the user with a valid state ID, the submission is not processed.
摘要翻译: 跨站点请求伪造(CSRF)和电子环境中的其他类型的欺诈提交可以使用通常已经为各种用户维护的状态信息来缓解。 需要认证的每个提交都包括状态标识符(ID)。 将状态ID与对应于以相对安全的格式提交的状态ID进行比较,例如在安全令牌或cookie中。 如果状态ID与从用户接收到的安全令牌中的状态ID相匹配,并且状态ID有效,则处理提交。 否则会生成包含状态ID和安全令牌的插页式页面,以提示用户确认提交。 随后的确认提交将包含正确的状态ID和新的cookie,并可以处理。 如果没有收到来自具有有效状态ID的用户的确认,则不处理该提交。
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公开(公告)号:US20120191813A1
公开(公告)日:2012-07-26
申请号:US13437380
申请日:2012-04-02
IPC分类号: G06F15/16
CPC分类号: H04M1/247 , H04L67/16 , H04L67/34 , H04M1/2535 , H04M7/0087 , H04W4/00 , H04W8/005
摘要: A method includes sending a request for network services to plural devices, where the request identifies the network services using a self-describing data structure, and receiving a response to the request from at least one device, where the response identifies which of the network services are supported by the at least one device.
摘要翻译: 一种方法包括向多个设备发送对网络服务的请求,其中请求使用自描述数据结构来标识网络服务,以及从至少一个设备接收对该请求的响应,其中该响应标识哪个网络服务 由所述至少一个设备支持。
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公开(公告)号:US5481020A
公开(公告)日:1996-01-02
申请号:US366830
申请日:1994-12-30
IPC分类号: C07C271/24 , C07C323/32 , C07C271/10
CPC分类号: C07C271/24 , C07C323/32 , C07C2102/42
摘要: Compounds of Formula 1 bind opioid receptors: which binds to the opioid receptor: ##STR1##
摘要翻译: 式1的化合物结合阿片受体:其结合阿片受体:
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公开(公告)号:US08539231B1
公开(公告)日:2013-09-17
申请号:US13585728
申请日:2012-08-14
申请人: Cyrus J. Durgin , Pratik S. Dave , Eric J. Martin
发明人: Cyrus J. Durgin , Pratik S. Dave , Eric J. Martin
IPC分类号: H04L29/06
CPC分类号: H04L63/06 , G06F21/602 , G06F21/604 , H04L9/0894 , H04L9/14 , H04L63/0428
摘要: Secure information is managed for each host or machine in an electronic environment using a series of key identifiers that each represent one or more secure keys, passwords, or other secure information. Applications and services needing access to the secure information can specify the key identifier, for example, and the secure information currently associated with that identifier can be determined without any change to the code or manual input or exposure of the secure information on the respective device. Functionality such as encryption key management and rotation are inaccessible and transparent to the user. In a networked or distributed environment, the key identifiers can be associated with host classes such that at startup any host in a class can obtain the necessary secure information. Updates and key rotation can be performed in a similar fashion by pushing updates to host classes transparent to a user, application, or service.
摘要翻译: 使用一系列关键标识符,每个代表一个或多个安全密钥,密码或其他安全信息,在电子环境中为每个主机或计算机管理安全信息。 需要访问安全信息的应用和服务可以指定密钥标识符,例如,可以确定当前与该标识符相关联的安全信息,而不改变代码或手动输入或者在相应设备上的安全信息的暴露。 诸如加密密钥管理和旋转等功能对于用户来说是无法访问和透明的。 在联网或分布式环境中,密钥标识符可以与主机类相关联,使得在启动时,类中的任何主机都可以获得必要的安全信息。 通过将更新推送给用户,应用程序或服务透明的主机类,可以以类似的方式执行更新和关键循环。
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公开(公告)号:US5747458A
公开(公告)日:1998-05-05
申请号:US485021
申请日:1995-06-07
申请人: Steve Rosenberg , Kerry L. Spear , Eric J. Martin
发明人: Steve Rosenberg , Kerry L. Spear , Eric J. Martin
IPC分类号: A61K38/00 , A61P9/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K5/06 , C07K5/083 , A61K38/06 , A61K38/07
CPC分类号: C07K5/0806 , A61K38/00
摘要: Compounds of the invention inhibit urokinase plasminogen activator: ##STR1## where R.sub.1 is lower alkyl, lower alkenyl, lower alkynyl, aryl, aralkyl, aryl-alkenyl, aryl-alkynyl, aryl-cycloalkyl, unsubstituted or substituted with 1-3 halo, OH, NH.sub.2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, CN or NO.sub.2 ; R.sub.2 is aryl or aralkyl, unsubstituted or substituted with 1-3 halo, OH, NH.sub.2, CN, NO.sub.2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, or cycloalkyl; R.sub.3, R.sub.5 and R.sub.9 are each independently H or lower alkyl; R.sub.4 is ##STR2## where R.sub.6 and R.sub.7 are each independently H, OH, NH.sub.2, CN, NO.sub.2, lower alkyl, halo-lower alkyl, lower alkoxy, lower alkylamino, lower alkylthio, or cycloalkyl, and n and m are each independently an integer from 1 to 3 inclusive; and pharmaceutically acceptable acid addition salts thereof.
摘要翻译: 本发明的化合物抑制尿激酶纤溶酶原激活剂:其中R 1是低级烷基,低级烯基,低级炔基,芳基,芳烷基,芳基 - 烯基,芳基 - 炔基,芳基 - 环烷基,未被取代或被1-3个卤素,OH ,NH 2,低级烷基,卤代低级烷基,低级烷氧基,低级烷基氨基,低级烷硫基,CN或NO 2; R 2是未取代或被1-3个卤素,OH,NH 2,CN,NO 2,低级烷基,卤代低级烷基,低级烷氧基,低级烷基氨基,低级烷硫基或环烷基取代的芳基或芳烷基。 R3,R5和R9各自独立地为H或低级烷基; R4是
,其中R6和R7各自独立地为H,OH,NH2,CN,NO2,低级烷基,卤代低级烷基,低级烷氧基,低级烷基氨基,低级烷硫基或环烷基,n和m各自独立地为 从1到3的整数; 及其药学上可接受的酸加成盐。 -
公开(公告)号:US5536868A
公开(公告)日:1996-07-16
申请号:US391132
申请日:1995-02-21
IPC分类号: C07C271/24 , C07C323/32 , C07C205/05 , C07C229/04 , C07C271/10
CPC分类号: C07C271/24 , C07C323/32 , C07C2102/42
摘要: Compounds of Formula 1 bind to the opioid receptors: ##STR1## wherein R.sub.1 is a group of the formula ##STR2## where W is --(CH.sub.2).sub.a -- (where a is 0, 1, or 2), --O--, --NH--, --S--, --SO--, or --SO.sub.2 --, and Ar is phenyl, phenyl-alkyl, phenyl substituted with 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups, and n is 0, 1, 2, 3, or 4;R.sub.2 and R.sub.3 are each independently H, lower alkyl, or ##STR3## where X is H, OH, lower alkyl, or lower alkoxy, and p is 0, 1, 2, or 3; R.sub.4 is ##STR4## where m is 0, 1, 2, or 3, and R is 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups;R.sub.5 is cycloalkyl, bicycloalkyl, or tricycloalkyl; andR.sub.6, R.sub.7, R.sub.8, and R.sub.9 are each independently H or lower alkyl.
摘要翻译: 式1的化合物与阿片受体结合:其中R 1是下式的基团:其中W是 - (CH 2)a - (其中a是0,1或2),-O-, - NH - , - S - , - SO-或-SO 2 - ,Ar是苯基,苯基 - 烷基,被1-3个卤素,硝基,低级烷基,羟基,氨基,烷基氨基,二烷基氨基和/或羟基 - 低级烷基,n为0,1,2,3或4; R 2和R 3各自独立地为H,低级烷基或者其中X为H,OH,低级烷基或低级烷氧基,p为0,1,2或3; R4是
,其中m是0,1,2或3,R是1-3个卤素,硝基,低级烷基,羟基,氨基,烷基氨基,二烷基氨基和/或羟基 - 低级烷基; R5是环烷基,双环烷基或三环烷基; 并且R 6,R 7,R 8和R 9各自独立地为H或低级烷基。 -
公开(公告)号:US5480871A
公开(公告)日:1996-01-02
申请号:US440108
申请日:1995-05-12
IPC分类号: C07C237/22 , C07K5/02 , C07K5/023 , C07K5/083 , G01N33/566 , G01N33/74 , G01N33/94 , A61K38/05 , A61K38/06
CPC分类号: C07C237/22 , C07K5/0202 , C07K5/0806 , G01N33/566 , G01N33/74 , G01N33/9433 , Y10S514/821 , Y10S514/824 , Y10S514/913
摘要: Compounds of the formula: ##STR1## are useful for treating conditions modulated by .alpha..sub.1 -adrenergic receptors.
摘要翻译: 下式的化合物:
可用于治疗由α1-肾上腺素能受体调节的病症。 -
公开(公告)号:US08621613B1
公开(公告)日:2013-12-31
申请号:US12471994
申请日:2009-05-26
申请人: Jon A. McClintock , Eric J. Martin , Karl A. McCabe , Thibault Candebat , Adam J. Cecchetti , David Erdmann
发明人: Jon A. McClintock , Eric J. Martin , Karl A. McCabe , Thibault Candebat , Adam J. Cecchetti , David Erdmann
IPC分类号: G06F21/00
CPC分类号: G06F21/566 , G06F21/56 , G06F21/567 , H04L63/145
摘要: Disclosed are various systems, methods, and other embodiments directed to detection of malware in content items. To detect the malware, for example, an environment is simulated in a computing device configured to render a network page having a container for content placement. The existence of malware in a content item is detected in the computing device by implementing a rendering of the network page in the environment with the content item inserted in the container to detect an unauthorized action by the content item.
摘要翻译: 公开了针对内容项目中的恶意软件的检测的各种系统,方法和其他实施例。 为了检测恶意软件,例如,在被配置为渲染具有用于内容放置的容器的网页的计算设备中模拟环境。 通过在内容项插入容器中的环境中实现网络页面的呈现来检测内容项目中的恶意软件的存在,以检测内容项目的未授权动作。
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