公开(公告)号：US09938302B2

公开(公告)日：2018-04-10

申请号：US15599401

申请日：2017-05-18

申请人： Bio TheryX, Inc.

发明人： Kyle W. H. Chan ,  Leah Fung ,  Robert Sullivan ,  Paul E. Erdman ,  Frank Mercurio ,  Eduardo Torres

IPC分类号： C07D513/16 ,  C07D487/00 ,  C07D403/04 ,  C07D409/14 ,  C07D247/02 ,  C07D225/02 ,  C07C223/02 ,  C07D221/00 ,  C07D209/00 ,  C07D207/04 ,  A61K38/00 ,  A61K31/437 ,  A61K39/00

CPC分类号： C07D513/16 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/06 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K9/7023 ,  A61K31/40 ,  A61K31/437 ,  A61K31/55 ,  A61K38/00 ,  A61K47/55 ,  A61K2039/505 ,  A61K2121/00 ,  C07C223/02 ,  C07D207/04 ,  C07D209/00 ,  C07D221/00 ,  C07D225/02 ,  C07D247/02 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/14 ,  C07D487/00 ,  C07D513/14

摘要： The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CK1-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as cytokine-mediated diseases, disorders, and conditions, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant rejection, and cancer, are provided.