公开(公告)号：US20240117067A1

公开(公告)日：2024-04-11

申请号：US18508938

申请日：2023-11-14

申请人： BioAtla, Inc.

发明人： Jay M. Short ,  Gerhard Frey ,  Hwai Wen Chang

IPC分类号： C07K16/30 ,  A61K47/68 ,  C07K16/28

CPC分类号： C07K16/30 ,  A61K47/6851 ,  C07K16/2809 ,  A61K2039/505

摘要： Isolated polypeptides having a heavy chain variable region and/or light chain variable region that specifically binds to EpCAM protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to EpCAM protein. Pharmaceutical compositions and kits comprising the polypeptide and antibodies and antibody fragments containing the polypeptide are also provided.

公开(公告)号：US20240092901A1

公开(公告)日：2024-03-21

申请号：US18457861

申请日：2023-08-29

申请人： BioAtla, Inc.

发明人： Jay M. Short ,  Hwai Wen Chang ,  Gerhard Frey

IPC分类号： C07K16/28 ,  A61K38/07 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00

CPC分类号： C07K16/2803 ,  A61K38/07 ,  A61K39/3955 ,  A61K47/6811 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/28 ,  A61K2039/505

摘要： A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to Ror2 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to Ror2 protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments containing the polypeptide are also provided.

公开(公告)号：US11851499B2

公开(公告)日：2023-12-26

申请号：US17616113

申请日：2020-06-10

申请人： BioAtla, Inc.

发明人： Jay M. Short ,  Gerhard Frey ,  Hwai Wen Chang

IPC分类号： C07K16/30 ,  A61K47/68 ,  A61K39/00 ,  C07K16/28

CPC分类号： C07K16/30 ,  A61K47/6851 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

摘要： Isolated polypeptides having a heavy chain variable region and/or light chain variable region that specifically binds to EpCAM protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to EpCAM protein Pharmaceutical compositions and kits comprising the polypeptide and antibodies and antibody fragments containing the polypeptide are also provided.

公开(公告)号：US11834472B2

公开(公告)日：2023-12-05

申请号：US16972357

申请日：2019-06-04

申请人： BioAtla, Inc.

发明人： Jay M. Short ,  Gerhard Frey ,  Hwai Wen Chang ,  William Boyle

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61K47/68 ,  A61P37/00 ,  A61P17/06 ,  A61K39/00

CPC分类号： C07K16/244 ,  A61K47/6803 ,  A61K47/6845 ,  A61P17/06 ,  A61P37/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/92 ,  C07K2317/94

摘要： An anti-IL-22 antibody or antibody fragment that binds to both human IL-22 and a mammalian IL-22 as well as modified anti-IL-22 antibodies and antibody fragments. Pharmaceutical compositions and kits comprising the antibody or antibody fragment are also provided. Also provided are methods for treatment of various IL-22 mediated conditions and diseases.

公开(公告)号：US11584927B2

公开(公告)日：2023-02-21

申请号：US16053166

申请日：2018-08-02

申请人： BioAtla, Inc.

发明人： Jay M. Short

IPC分类号： C12N15/10 ,  C07K14/705 ,  C07K14/725 ,  C07K14/735 ,  C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00

摘要： This disclosure relates to a chimeric antigen receptor for binding with a target antigen. The chimeric antigen receptor comprises at least one antigen specific targeting region including a multispecific antibody evolved from a wild-type antibody or a fragment thereof and having at least one of: (a) a decrease in activity in the assay at the normal physiological condition compared to the wild-type antibody or the fragment thereof, and (b) an increase in activity in the assay under the aberrant condition compared to the wild-type antibody or the fragment thereof. A method for using the chimeric antigen receptor and cytotoxic cells for cancer treatment is also provided. A method for producing the chimeric antigen receptor is also provided.

公开(公告)号：US20220341941A1

公开(公告)日：2022-10-27

申请号：US17680101

申请日：2022-02-24

申请人： BioAtla, Inc.

发明人： Jay M. Short

IPC分类号： G01N33/68 ,  G01N33/573 ,  G01N33/543

摘要： The present invention is relevant to polypeptides and novel methods of polypeptide evolution. The present invention further relates to methods of identifying a cross-species mutant polypeptide from, or based upon, a template polypeptide.

公开(公告)号：US20210403577A1

公开(公告)日：2021-12-30

申请号：US17465968

申请日：2021-09-03

申请人： BioAtla, Inc.

发明人： Jay M. Short ,  Hwai Wen Chang ,  Gerhard Frey

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K47/65 ,  A61P35/00

摘要： An antibody or antibody fragment having a heavy chain variable region and/or light chain variable region that specifically binds to Axl protein. Immuoconjugages, pharmaceutical compositions and kits comprising the antibodies and antibody fragments are also provided. Also disclosed are methods of treating Axl-expressing cancers using the antibodies, antibody fragments, immunoconjugates and pharmaceutical compositions of the present invention.

公开(公告)号：US20210403565A1

公开(公告)日：2021-12-30

申请号：US17288187

申请日：2019-10-25

申请人： BioAtla, Inc.

发明人： Jay M. Short ,  Gerhard Frey ,  Hwai Wen Chang

IPC分类号： C07K16/28 ,  A61K47/68

摘要： A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to CTLA4 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to CTLA4 protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments containing the polypeptide are also provided.

公开(公告)号：US20210017221A1

公开(公告)日：2021-01-21

申请号：US17039510

申请日：2020-09-30

申请人： BIOATLA, Inc.

发明人： Jay M. Short

IPC分类号： C07K1/107 ,  G16B20/00 ,  C07K1/04 ,  C12N15/10 ,  G01N33/68

摘要： The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from, or based upon, a template polypeptide.

公开(公告)号：US12110611B2

公开(公告)日：2024-10-08

申请号：US17573389

申请日：2022-01-11

申请人： BIOATLA, INC.

发明人： Jay M. Short ,  Hwai Wen Chang ,  Gerhard Frey

IPC分类号： C40B30/04 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C12N15/10 ,  C40B40/08 ,  C40B40/10

CPC分类号： C40B30/04 ,  C07K16/00 ,  C07K16/005 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/30 ,  C12N15/1058 ,  C12N15/1093 ,  C40B40/08 ,  C40B40/10 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/90 ,  C07K2317/94

摘要： Methods of generating conditionally active biologic proteins, in particular therapeutic or diagnostic proteins, which are more active at an aberrant condition than at a normal physiological condition. The methods include discovery methods using libraries of proteins and assays employing physiological concentrations of components of bodily fluids. The conditionally active biologic proteins may be further evolved, conjugated to other molecules, masked, reduced in activity by attaching a cleavable moiety. Criteria for selecting starting proteins for the discovery methods, as well as formats of the proteins are also disclosed.