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1.发明授权公开(公告)号：US12043610B2
公开(公告)日：2024-07-23
申请号：US17730463
申请日：2022-04-27
发明人： Pravin L. Kotian , Yarlagadda S. Babu , Weihe Zhang , Peng-Cheng Lu , Minwan Wu , Wei Lv , Trung Xuan Nguyen , Zhao Dang , Venkat R. Chintareddy , V. Satish Kumar , Krishnan Raman
IPC分类号： C07D401/10 , C07D209/12 , C07D261/20 , C07D307/80 , C07D333/64 , C07D401/12 , C07D405/10
CPC分类号： C07D401/10 , C07D209/12 , C07D261/20 , C07D307/80 , C07D333/64 , C07D401/12 , C07D405/10
摘要： Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
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公开(公告)号：US20240239752A1
公开(公告)日：2024-07-18
申请号：US18286615
申请日：2022-04-14
发明人： Pravin L. Kotian , Yarlagadda S. Babu , Weihe Zhang , Peng-Cheng Lu , Zhao Dang , Krishnan Raman
IPC分类号： C07D231/56 , A61K31/343 , A61K31/352 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4375 , A61K31/443 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5025 , A61K31/517 , A61K31/519 , C07D217/22 , C07D307/81 , C07D311/96 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D231/56 , A61K31/343 , A61K31/352 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4375 , A61K31/443 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5025 , A61K31/517 , A61K31/519 , C07D217/22 , C07D307/81 , C07D311/96 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds of formulae (I)-(IV), and pharmaceutically acceptable salts thereof, which are inhibitors of kallikrein-related peptidase 5 (KLK5). Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant KLK5 activity, such as Netherton Syndrome.
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公开(公告)号：US11708332B2
公开(公告)日：2023-07-25
申请号：US17526377
申请日：2021-11-15
发明人： Pravin L. Kotian , Yarlagadda S. Babu , Minwan Wu , Venkat R. Chintareddy , V. Satish Kumar , Weihe Zhang
IPC分类号： C07D231/14 , C07D403/12 , C07D401/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/12
CPC分类号： C07D231/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds of formula I
as described herein, and pharmaceutically acceptable salts thereof. The compounds are disclosed to be inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.-
公开(公告)号：US20220332723A1
公开(公告)日：2022-10-20
申请号：US16622816
申请日：2018-06-14
发明人： Pravin L. Kotian , Yarlagadda S. Babu , V. Satish Kumar , Weihe Zhang , Peng-Cheng Lu , Krishnan Raman
IPC分类号： C07D491/048 , C07D487/04 , C07D495/04 , C07D403/12 , C07D403/14 , C07D471/04 , C07D513/04 , C07D401/14 , C07D405/14 , C07D405/12
摘要： Disclosed are compounds of formula I, II, III, and IV, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of ALK2 kinase. Also provided are pharmaceutical compositions comprising a compound of formula I, II, III, or IV, or pharmaceutically acceptable salt thereof, and methods involving use of the compounds or pharmaceutically acceptable salts thereof and compositions in the treatment and prevention of various diseases and conditions, such as fibrodysplasia ossificans progressiva.
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公开(公告)号：US10512649B2
公开(公告)日：2019-12-24
申请号：US16082437
申请日：2017-03-06
IPC分类号： A61K31/519 , C07D487/04 , A61P31/14 , A61K9/00
摘要： Disclosed are 9-deazaaadenine derivatives of the general formula (I) and pharmaceutically acceptable salts thereof, wherein A is OH or NH2, and B is H or NH2. Methods for treating, preventing and/or suppressing a Zika virus infection with the compounds disclosed are also provided. Pharmaceutical compositions comprising the disclosed compounds are also provided. Such pharmaceutical compositions may optionally contain one or more additional active agents.
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公开(公告)号：US10420769B2
公开(公告)日：2019-09-24
申请号：US16013059
申请日：2018-06-20
IPC分类号： A61K31/519 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/7064 , A61K45/06 , C07H7/06 , C07D487/04 , A61K9/00 , A61P31/14 , A61P31/16
摘要： The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional anti-viral agents.
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公开(公告)号：US10329260B2
公开(公告)日：2019-06-25
申请号：US15977129
申请日：2018-05-11
发明人： Pravin L. Kotian , Yarlagadda S. Babu , Minwan Wu , Venkat R. Chintareddy , V. Satish Kumar , Weihe Zhang
IPC分类号： C07D231/14 , C07D417/12 , C07D413/12 , C07D413/04 , C07D405/12 , C07D403/12 , C07D401/12 , C07D401/04 , C07D401/14 , C07D403/04
摘要： Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also disclosed are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.
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公开(公告)号：US09499554B2
公开(公告)日：2016-11-22
申请号：US14890719
申请日：2014-05-14
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D471/04 , A61K31/13 , A61K45/06
CPC分类号： C07D487/04 , A61K31/13 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/385 , Y02A50/387 , Y02A50/465 , A61K2300/00
摘要： Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.
摘要翻译： 公开了包含与碳环或杂环共价连接的亚氨基 - 核糖衍生物的新型化合物。 还描述了包含本发明化合物的药物组合物。 还描述了用本发明化合物进行病毒感染的抑制，治疗和/或抑制的方法。 组合物或方法可以任选地包含一种或多种另外的抗病毒剂。
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公开(公告)号：US20150051230A1
公开(公告)日：2015-02-19
申请号：US14531471
申请日：2014-11-03
IPC分类号： A61K31/519 , A61K31/196 , C07D487/04
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/7064 , A61K45/06 , A61P31/14 , A61P31/16 , C07D487/04 , C07H7/06 , Y02A50/385 , Y02A50/393 , Y02A50/397 , A61K2300/00
摘要： The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional anti-viral agents.
摘要翻译： 本发明涉及用于抑制病毒核酸聚合酶例如RNA和DNA聚合酶的方法和组合物，以及可用于治疗受试者的病毒感染的方法和组合物。 所述方法包括向受试者施用治疗有效量的式I化合物或其药学上可接受的盐或水合物，或包含式I化合物或其药学上可接受的盐或水合物的组合物和药学上可接受的 载体 组合物或方法可任选地包含一种或多种另外的抗病毒剂。
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公开(公告)号：US11661426B2
公开(公告)日：2023-05-30
申请号：US16622816
申请日：2018-06-14
发明人： Pravin L. Kotian , Yarlagadda S. Babu , V. Satish Kumar , Weihe Zhang , Peng-Cheng Lu , Krishnan Raman
IPC分类号： C07D401/14 , C07D491/048 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07D491/048 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds of formula I, II, III, and IV, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of ALK2 kinase. Also provided are pharmaceutical compositions comprising a compound of formula I, II, III, or IV, or pharmaceutically acceptable salt thereof, and methods involving use of the compounds or pharmaceutically acceptable salts thereof and compositions in the treatment and prevention of various diseases and conditions, such as fibrodysplasia ossificans progressiva.
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