公开(公告)号：US09068992B2

公开(公告)日：2015-06-30

申请号：US13802249

申请日：2013-03-13

Applicant: Biogen Idec MA Inc.

Inventor： Sha Mi ,  R. Blake Pepinsky ,  John McCoy

IPC: G01N33/567 ,  G01N33/48 ,  C07K14/00 ,  G01N33/68 ,  A61K38/17

CPC classification number: G01N33/6893 ,  A61K38/17 ,  A61K38/1709 ,  C07K2319/30

Abstract: The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist.

Abstract translation: 本发明提供了通过施用Sp35拮抗剂治疗涉及脱髓鞘和髓鞘脱离（包括多发性硬化）的疾病，病症或损伤的方法。

公开(公告)号：US20150177240A1

公开(公告)日：2015-06-25

申请号：US14557653

申请日：2014-12-02

Applicant: Biogen Idec MA Inc.

Inventor： Sha Mi ,  John McCoy ,  R. Blake Pepinsky ,  Daniel H.S. Lee

IPC: G01N33/569 ,  C12N5/0793

CPC classification number: G01N33/56966 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/70571 ,  C07K16/18 ,  C07K16/2803 ,  C07K2319/30 ,  C12N5/0619 ,  C12N2500/46 ,  G01N33/5058 ,  G01N33/6896

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract translation: 本发明提供了Sp35多肽及其融合蛋白，Sp35抗体及其抗原结合片段和编码其的核酸。 本发明还提供了包含此类Sp35抗体，其抗原结合片段，Sp35多肽及其融合蛋白的制备和使用方法。

公开(公告)号：US08932821B2

公开(公告)日：2015-01-13

申请号：US13827771

申请日：2013-03-14

Applicant: Biogen Idec MA Inc.

Inventor： Sha Mi ,  John McCoy ,  R. Blake Pepinsky ,  Daniel H. S. Lee

IPC: G01N33/53 ,  G01N33/50 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  G01N33/68 ,  A61K38/00

CPC classification number: G01N33/56966 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/70571 ,  C07K16/18 ,  C07K16/2803 ,  C07K2319/30 ,  C12N5/0619 ,  C12N2500/46 ,  G01N33/5058 ,  G01N33/6896

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract translation: 本发明提供了Sp35多肽及其融合蛋白，Sp35抗体及其抗原结合片段和编码其的核酸。 本发明还提供了包含此类Sp35抗体，其抗原结合片段，Sp35多肽及其融合蛋白的制备和使用方法。

公开(公告)号：US20130273558A1

公开(公告)日：2013-10-17

申请号：US13802249

申请日：2013-03-13

Applicant: Biogen Idec MA Inc.

Inventor： Sha MI ,  R. Blake Pepinsky ,  John McCoy

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  A61K38/17 ,  A61K38/1709 ,  C07K2319/30

Abstract: The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist.

Abstract translation: 本发明提供了通过施用Sp35拮抗剂治疗涉及脱髓鞘和髓鞘脱离（包括多发性硬化）的疾病，病症或损伤的方法。