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公开(公告)号：US20140309212A1
公开(公告)日：2014-10-16
申请号：US14316710
申请日：2014-06-26
Applicant: Biogen Idec MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/04 , C07D401/04 , C07D417/14 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20140227266A1
公开(公告)日：2014-08-14
申请号：US14146345
申请日：2014-01-02
Applicant: Biogen Idec MA Inc.
Inventor： Daniel H.S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
IPC: C07K16/28 , A61K38/17 , C12N15/113 , C07K14/705 , A61K39/395
CPC classification number: C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的拮抗剂多核苷酸的核酸和制备和使用的组合物。
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3.发明授权公开(公告)号：US09228015B2
公开(公告)日：2016-01-05
申请号：US14146345
申请日：2014-01-02
Applicant: Biogen Idec MA Inc.
Inventor： Daniel H. S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
IPC: C07K16/28 , A01K67/027 , C07K14/705 , C12N15/113 , C12N15/85 , A61K38/17 , A61K39/395 , A61K48/00 , A61K39/00
CPC classification number: C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的核苷酸和拮抗剂多核苷酸的制备和使用方法。
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公开(公告)号：US09249146B2
公开(公告)日：2016-02-02
申请号：US14316710
申请日：2014-06-26
Applicant: Biogen Idec MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D401/04 , A61K31/519 , C07D487/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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