公开(公告)号：US09228015B2

公开(公告)日：2016-01-05

申请号：US14146345

申请日：2014-01-02

Applicant: Biogen Idec MA Inc.

Inventor： Daniel H. S. Lee ,  Dingyi Wen ,  R. Blake Pepinsky ,  Jane K. Relton ,  Xinzhong Wang ,  Alexey Lugovskoy ,  Werner Meier ,  Ellen A. Garber ,  Laura Silvian ,  Paul H. Weinreb

IPC: C07K16/28 ,  A01K67/027 ,  C07K14/705 ,  C12N15/113 ,  C12N15/85 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  A61K39/00

CPC classification number: C07K14/705 ,  A01K67/027 ,  A01K67/0275 ,  A01K2217/058 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/179 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/1136 ,  C12N15/1138 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的核苷酸和拮抗剂多核苷酸的制备和使用方法。

公开(公告)号：US20150140609A1

公开(公告)日：2015-05-21

申请号：US14444701

申请日：2014-07-28

Applicant: BIOGEN IDEC MA INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Kenneth J. Simon ,  Dean Sheppard ,  Diane R. Leone

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  A61K47/48507 ,  A61K47/48561 ,  A61K47/48623 ,  A61K47/68 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6865 ,  A61K51/1027 ,  A61K51/1066 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/085 ,  G01N2800/205

Abstract: Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Q mediated diseases.

Abstract translation: 特异性结合M.96的单克隆抗体。 还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。

公开(公告)号：US20140294809A1

公开(公告)日：2014-10-02

申请号：US14161207

申请日：2014-01-22

Applicant: BIOGEN IDEC MA INC.

Inventor： Shelia M. Violette ,  Louise A. Koopman ,  Kenneth J. Simon ,  Paul H. Weinreb ,  Herman W.T. Van Vlijmen ,  Jose W. Saldanha ,  Alexey A. Lugovskoy

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/77 ,  G01N33/57407 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/085 ,  G01N2800/12 ,  G01N2800/20 ,  G01N2800/347 ,  Y10S424/80 ,  Y10S424/801

Abstract: The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.

Abstract translation: 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。

公开(公告)号：US20140227266A1

公开(公告)日：2014-08-14

申请号：US14146345

申请日：2014-01-02

Applicant: Biogen Idec MA Inc.

Inventor： Daniel H.S. Lee ,  Dingyi Wen ,  R. Blake Pepinsky ,  Jane K. Relton ,  Xinzhong Wang ,  Alexey Lugovskoy ,  Werner Meier ,  Ellen A. Garber ,  Laura Silvian ,  Paul H. Weinreb

IPC: C07K16/28 ,  A61K38/17 ,  C12N15/113 ,  C07K14/705 ,  A61K39/395

CPC classification number: C07K14/705 ,  A01K67/027 ,  A01K67/0275 ,  A01K2217/058 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/179 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/1136 ,  C12N15/1138 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

Abstract translation: 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的拮抗剂多核苷酸的核酸和制备和使用的组合物。