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公开(公告)号：US20150359826A1
公开(公告)日：2015-12-17
申请号：US14837281
申请日：2015-08-27
IPC分类号： A61K35/62 , A01K67/033 , A61K31/555 , A61K45/06 , A61K31/4745
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a melanoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 还提供了用于分离和使用全唾液水蛭提取物治疗黑素瘤的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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公开(公告)号：US20150196607A1
公开(公告)日：2015-07-16
申请号：US14670262
申请日：2015-03-26
IPC分类号： A61K35/62 , A61K31/4745 , A61K31/282 , A61K45/06
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of pancreatic carcinoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 还提供了用于分离和使用全唾液水蛭提取物治疗胰腺癌的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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3.发明申请TREATING DAMAGED DERMAL OR MUCOSAL TISSUE WITH A WHOLE, LEECH SALIVA EXTRACT 审中-公开用全身，LALAL SALIVA提取物治疗损伤的皮肤或粘膜组织公开(公告)号：US20160331789A1
公开(公告)日：2016-11-17
申请号：US15222180
申请日：2016-07-28
IPC分类号： A61K35/62
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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4.发明申请TREATING PROSTATE, OVARIAN, OR BREAST CANCER WITH A WHOLE, LEECH SALIVA EXTRACT 审中-公开治疗前列腺癌，卵巢癌或乳腺癌全身，LELLAL SALIVA提取物公开(公告)号：US20140356448A1
公开(公告)日：2014-12-04
申请号：US14282865
申请日：2014-05-20
IPC分类号： A61K35/62 , A61K31/282 , A61K31/4745
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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公开(公告)号：US20150086645A1
公开(公告)日：2015-03-26
申请号：US14552388
申请日：2014-11-24
IPC分类号： A61K35/62 , A61K31/555 , A61K31/4745
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/40 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/479 , Y02A50/481 , Y02A50/483 , Y02A50/491 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。
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