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公开(公告)号：US09982036B2
公开(公告)日：2018-05-29
申请号：US13406411
申请日：2012-02-27
申请人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
发明人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/41 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.
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公开(公告)号：US20120237506A1
公开(公告)日：2012-09-20
申请号：US13406411
申请日：2012-02-27
申请人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
发明人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/41 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.
摘要翻译： 本发明涉及包含两个Fc部分的抗原结合蛋白，其制备方法，含有所述抗原结合蛋白的药物组合物及其用途。
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公开(公告)号：US20120237507A1
公开(公告)日：2012-09-20
申请号：US13406503
申请日：2012-02-27
申请人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
发明人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
CPC分类号： C07K16/00 , C07K16/2863 , C07K2317/35 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to monovalent antigen binding proteins with a CH1-CL domain exchange, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及具有CH1-CL结构域交换的单价抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100254989A1
公开(公告)日：2010-10-07
申请号：US12753145
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-1 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-1和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US20100254988A1
公开(公告)日：2010-10-07
申请号：US12753141
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-2 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-2和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US20100256339A1
公开(公告)日：2010-10-07
申请号：US12752196
申请日：2010-04-01
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-3和针对人c-Met的双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US20110052582A1
公开(公告)日：2011-03-03
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US07205326B2
公开(公告)日：2007-04-17
申请号：US10833721
申请日：2004-04-28
IPC分类号： A61K31/422 , C07D263/30 , C07D413/02
CPC分类号： C07D413/12 , C07D413/14
摘要： Compounds of formula (I) are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.
摘要翻译： 式（I）化合物
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公开(公告)号：US20050267179A1
公开(公告)日：2005-12-01
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： A61K31/422 , A61P35/00 , C07D413/02 , C07D413/12
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法，以及上述化合物在 控制或预防癌症等疾病。
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10.发明申请Novel arylazole derivatives, their manufacture and use as pharmaceutical agents 失效新型芳基唑衍生物，其制造和用作药剂公开(公告)号：US20050124670A1
公开(公告)日：2005-06-09
申请号：US10965996
申请日：2004-10-15
IPC分类号： A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/426 , C07D413/14 , C07D417/14 , C07D277/38 , A61K31/427 , C07D413/02 , C07D417/02
CPC分类号： C07D417/14 , C07D413/14
摘要： There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 提供式（I）化合物的药学上可接受的盐，其对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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