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1.发明授权Process for screening chemical compounds for modulating the interaction of an EVH1 domain and a process for detecting said interaction 失效用于筛选化合物以调节EVH1结构域的相互作用和用于检测所述相互作用的方法的方法公开(公告)号：US07563582B2
公开(公告)日：2009-07-21
申请号：US09989188
申请日：2001-11-21
申请人： Birgit Jordan , Peter Drückes , Thomas Jarchau , Ulrich Walter
发明人： Birgit Jordan , Peter Drückes , Thomas Jarchau , Ulrich Walter
IPC分类号： G01N33/53 , G01N33/535
CPC分类号： G01N33/6845 , G01N33/542 , G01N33/574 , G01N2500/00
摘要： The invention relates to processes for identifying chemical compounds which are capable of modulating the interaction between VASP and zyxin. VASP or a VASP derivative and zyxin or a zyxin derivative which interact with one another are brought into contact with a chemical compound to be examined. The effect on the interaction can be determined using antibodies against VASP or a VASP derivative and/or zyxin or a zyxin derivative, or with the aid of fluorescent labels on VASP or a VASP derivative and zyxin or a zyxin derivative.
摘要翻译： 本发明涉及鉴定化合物的方法，该化合物能够调节VASP和zyxin之间的相互作用。 使彼此相互作用的VASP或VASP衍生物和zyxin或zyxin衍生物与待检查的化合物接触。 可以使用针对VASP或VASP衍生物和/或zyxin或zyxin衍生物的抗体或借助于VASP或VASP衍生物和zyxin或zyxin衍生物上的荧光标记来确定对相互作用的影响。
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2.发明授权Cyclohexapeptides and their mixtures, a process for preparing them, and their use 失效环己肽及其混合物，其制备方法及其用途
公开(公告)号：US6080719A
公开(公告)日：2000-06-27
申请号：US606711
申请日：1996-02-23
申请人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
发明人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
摘要： The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in which A, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
摘要翻译： 本发明涉及式I环（ABCEF-（D）-Ala）（I）的化合物，其中A，B，C，E和F各自独立地是除半胱氨酸（Cys）和色氨酸之外的天然氨基酸的残基 （Trp），它们的混合物及其生理耐受盐; 其制备方法及其用于制备诊断剂的用途，用于治疗或预防过敏和感染的药物，或用于抑制白细胞介素-4（IL-4）与IL-4（IL-4）结合的科学工具 受体。
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公开(公告)号：US5869447A
公开(公告)日：1999-02-09
申请号：US571797
申请日：1995-12-13
申请人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
发明人： Stephan Henke , Birgit Jordan , Jochen Knolle , Leander Lauffer , Susanne Feiertag , Karl-Heinz Wiesmuller , Gunther Jung
摘要： The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in whichA, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
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