公开(公告)号：US20050014712A1

公开(公告)日：2005-01-20

申请号：US10776934

申请日：2004-02-10

申请人： Bo Hansen ,  Charlotte Thrue ,  Majken Westergaard ,  Kamille Petersen ,  Margit Wissenbach

发明人： Bo Hansen ,  Charlotte Thrue ,  Majken Westergaard ,  Kamille Petersen ,  Margit Wissenbach

IPC分类号： C07H21/04 ,  A61K48/00

CPC分类号： C07H21/04

摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

公开(公告)号：US20100292311A1

公开(公告)日：2010-11-18

申请号：US12765673

申请日：2010-04-22

申请人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

发明人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

IPC分类号： A61K31/713 ,  A61P35/00

CPC分类号： C07H21/04

摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

公开(公告)号：US20120088907A1

公开(公告)日：2012-04-12

申请号：US13183365

申请日：2011-07-14

申请人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

发明人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

IPC分类号： C07H21/04

CPC分类号： C07H21/04

摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

公开(公告)号：US07713738B2

公开(公告)日：2010-05-11

申请号：US10776934

申请日：2004-02-10

申请人： Bo Hansen ,  Charlotte Albæk Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

发明人： Bo Hansen ,  Charlotte Albæk Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

IPC分类号： C12N5/00

CPC分类号： C07H21/04

摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

公开(公告)号：US20080188432A1

公开(公告)日：2008-08-07

申请号：US11640123

申请日：2006-12-15

申请人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

发明人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

IPC分类号： A61K31/7052 ,  C07H21/04

CPC分类号： C12N15/1135 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/33 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346

摘要： Oligonucleotides directed against the Ha-ras gene are provided for modulating the expression of Ha-ras. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Ha-ras. Methods of using these compounds for modulation of Ha-ras expression and for the treatment of diseases associated with either overexpression of Ha-ras, expression of mutated Ha-ras or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

摘要翻译： 提供针对Ha-ras基因的寡核苷酸用于调节Ha-ras的表达。 组合物包含针对编码Ha-ras的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节Ha-ras表达和治疗与Ha-ras的过表达有关的疾病，突变型Ha-ras或两者的表达的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

公开(公告)号：US20090118213A1

公开(公告)日：2009-05-07

申请号：US12066852

申请日：2006-09-01

申请人： Henrik Frydenlund Hansen ,  Bo Hansen ,  Majken Westergaard ,  Ellen Marie Straarup ,  Christoph Rosenbohm

发明人： Henrik Frydenlund Hansen ,  Bo Hansen ,  Majken Westergaard ,  Ellen Marie Straarup ,  Christoph Rosenbohm

IPC分类号： A61K31/7088 ,  C07H21/04

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515

摘要： Oligonucleotides directed against the Apo-B100 gene are provided for modulating the expression of Apo-B100. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Apo-B100. Methods of using these compounds for modulation of Apo-B100 expression and for the treatment of diseases associated with either overexpression of Apo-B100, expression of mutated Apo-B100 or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

摘要翻译： 提供针对Apo-B100基因的寡核苷酸用于调节Apo-B100的表达。 组合物包含针对编码Apo-B100的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节Apo-B100表达和治疗与Apo-B100的过度表达相关的疾病，突变的Apo-B100或两者的表达的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

公开(公告)号：US20140133269A1

公开(公告)日：2014-05-15

申请号：US14232034

申请日：2011-07-12

申请人： Bo Hansen

发明人： Bo Hansen

IPC分类号： G01S7/52 ,  A61B8/00 ,  A61B8/12

CPC分类号： G01S7/52017 ,  A61B1/00078 ,  A61B8/12 ,  A61B8/445

摘要： An elongate probe (204) including a probe head (214) with a transducer array (216), a shaft (210) and an articulating member (212). The articulating member is located between the probe head and the shaft. The articulating member is configured to articulate between a position in which the probe head extends along a longitudinal axis of the probe and at least one articulated position in which the probe head extends at a non-zero angle from the longitudinal axis of the probe. The probe further includes a stiffener (224) configured to controllably move from a retracted position to an extended position at which the stiffener inhibits articulation of the articulating member.

摘要翻译： 包括具有换能器阵列（216）的探针头（214），轴（210）和铰接构件（212）的细长探针（204）。 铰接构件位于探头和轴之间。 所述铰接构件被构造成在所述探针头沿着所述探针的纵向轴线延伸的位置与所述探针头与所述探针的纵向轴线成非零角度延伸的至少一个铰接位置之间铰接。 探头还包括加强件（224），该加强件构造成可控地从缩回位置移动到延伸位置，在该位置处，加强件抑制铰接构件的铰接。

公开(公告)号：US09897694B2

公开(公告)日：2018-02-20

申请号：US14232034

申请日：2011-07-12

申请人： Bo Hansen

发明人： Bo Hansen

IPC分类号： A61B8/12 ,  G01S7/52 ,  A61B1/00 ,  A61B8/00

CPC分类号： G01S7/52017 ,  A61B1/00078 ,  A61B8/12 ,  A61B8/445

摘要： An elongate probe (204) including a probe head (214) with a transducer array (216), a shaft (210) and an articulating member (212). The articulating member is located between the probe head and the shaft. The articulating member is configured to articulate between a position in which the probe head extends along a longitudinal axis of the probe and at least one articulated position in which the probe head extends at a non-zero angle from the longitudinal axis of the probe. The probe further includes a stiffener (224) configured to controllably move from a retracted position to an extended position at which the stiffener inhibits articulation of the articulating member.

公开(公告)号：US20080240978A1

公开(公告)日：2008-10-02

申请号：US11979751

申请日：2007-11-08

申请人： Jan Sorensen ,  Carl F. Simony ,  Bo Hansen

发明人： Jan Sorensen ,  Carl F. Simony ,  Bo Hansen

IPC分类号： A61L2/025 ,  A61L2/20 ,  A61L2/07

CPC分类号： A61L2/186 ,  A61L2/183 ,  A61L2/202 ,  A61L2/208 ,  A61L2202/24

摘要： The present invention relates to the field of sterilization of items that are sensitive to e.g. temperature, pH, positive or negative pressure, radiation or oxidation. More particularly, the invention concerns a method, the use of this method and an apparatus for sterilization or disinfection, comprising the steps of contacting one or more item or part of an item with (a) a water-based fluid containing at least one enzyme, and (b) a substantially water-free environment with a gas having oxidative properties, where said step (a) precedes said step (b). According to the invention, items can be sterilized that are otherwise impaired by conventional sterilization procedures, such as laboratory items, medical items, dental items, military items, biological items, and food processing-related items.

摘要翻译： 本发明涉及对例如敏感的物品的灭菌领域。 温度，pH，正压或负压，辐射或氧化。 更具体地，本发明涉及一种方法，该方法的使用和用于灭菌或消毒的设备，包括以下步骤：将一个或多个物品或部分物品与（a）含有至少一种酶的水基流体接触 ，和（b）具有氧化性质的气体的基本上无水的环境，其中所述步骤（a）在所述步骤（b）之前。 根据本发明，可以对诸如实验室物品，医疗物品，牙科用品，军事物品，生物制品和食品加工相关物品的常规灭菌程序进一步损害的物品进行灭菌。