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公开(公告)号：US20190093085A1
公开(公告)日：2019-03-28
申请号：US16020738
申请日：2018-06-27
发明人： Frank Tufaro , Juan Fueyo-Margareto , Candelaria Gomez-Manzano , Charles Conrad , Alfred W.K. Yung , Hong Jiang
IPC分类号： C12N7/00 , A61K35/761 , A61K45/06 , C07K14/52 , A61K31/495 , A61K38/21
摘要： Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
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公开(公告)号：US10080774B2
公开(公告)日：2018-09-25
申请号：US14703876
申请日：2015-05-04
发明人： Juan Fueyo , Candelaria Gomez-Manzano , W. K. Alfred Yung , Charles A. Conrad , Frederick F. Lang, Jr.
IPC分类号： A61K35/761 , A61K31/513 , A61K38/17 , A61K38/18 , A61K38/50 , A61K45/06 , A61K48/00 , C12N15/86 , C07K14/005 , C12N7/00 , A61K38/00
CPC分类号： A61K35/761 , A61K31/513 , A61K38/00 , A61K38/177 , A61K38/1891 , A61K38/50 , A61K45/06 , A61K48/005 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10032 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12Y305/04001 , A61K2300/00
摘要： The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
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3.发明申请BIOMARKERS AND COMBINATION THERAPIES USING ONCOLYTIC VIRUS AND IMMUNOMODULATION 审中-公开生物标记物和使用光感病毒和免疫调节的组合治疗公开(公告)号：US20140377221A1
公开(公告)日：2014-12-25
申请号：US14374619
申请日：2013-01-25
发明人： Frank Tufaro , Charles Conrad , Juan Fueyo-Margareto , Frederick Lang , Candelaria Gomez-Manzano , W.K. Alfred Yung , Amy Heimberger
IPC分类号： A61K35/76 , A61K38/21 , C07K16/28 , A61K39/395 , C12N7/00 , G01N33/574 , A61K38/20
CPC分类号： A61K35/761 , A61K38/2013 , A61K38/208 , A61K38/217 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/2818 , C07K2317/21 , C07K2317/76 , C12N7/00 , C12N2710/10033 , C12N2710/10332 , G01N33/57484 , G01N33/57488 , G01N2333/52 , G01N2800/52 , A61K2300/00 , A61K39/39558
摘要： The invention disclosed herein describes biomarkers useful for prognosis, selection and monitoring of oncolytic virus therapy for patients with various types of cancer. In particular, the present invention provides identification of proteins whose expression patterns are strongly predictive of the outcome of oncolytic virus therapy in a patient with cancer. The present invention provides a method for identifying and selecting cancer patients who are likely to be non-responsive to onocolytic virus therapy. These patients can be co-administered an agent that stimulates a cell-mediated immune response in the patient with the oncolytic virus or can be administered a therapy other than oncolytic virus therapy.
摘要翻译： 本文公开的发明描述了可用于预后，选择和监测各种癌症患者的溶瘤病毒治疗的生物标志物。 特别地，本发明提供蛋白质的鉴定，其表达模式强烈地预测癌症患者中溶瘤病毒治疗的结果。 本发明提供了一种鉴定和选择可能对解卷病毒治疗无反应的癌症患者的方法。 这些患者可以共同施用刺激患有溶瘤病毒的患者中的细胞介导的免疫应答的试剂，或者可以施用不同于溶瘤病毒治疗的治疗。
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公开(公告)号：US11090344B2
公开(公告)日：2021-08-17
申请号：US16304359
申请日：2017-05-30
发明人： Frank Tufaro , Juan Fueyo-Margareto , Candelaria Gomez-Manzano , Charles Conrad , W. K. Alfred Yung , Hong Jiang
IPC分类号： A61K35/761 , C07K16/28 , C12N15/86 , A61K9/00 , A61K39/395 , A61P35/04
摘要： Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
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公开(公告)号：US11065285B2
公开(公告)日：2021-07-20
申请号：US16917170
申请日：2020-06-30
发明人： Frank Tufaro , Charles Conrad , Juan Fueyo-Margareto , Frederick Lang, Jr. , Candelaria Gomez-Manzano , W.K. Alfred Yung , Amy Heimberger
IPC分类号： A61K35/761 , G01N33/574 , A61K38/20 , A61K38/21 , C07K16/28 , A61K45/06 , A61K39/395 , C12N7/00 , A61K39/00
摘要： The invention disclosed herein describes biomarkers useful for prognosis, selection and monitoring of oncolytic virus therapy for patients with various types of cancer. In particular, the present invention provides identification of proteins whose expression patterns are strongly predictive of the outcome of oncolytic virus therapy in a patient with cancer. The present invention provides a method for identifying and selecting cancer patients who are likely to be non-responsive to onocolytic virus therapy. These patients can be co-administered an agent that stimulates a cell-mediated immune response in the patient with the oncolytic virus or can be administered a therapy other than oncolytic virus therapy.
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公开(公告)号：US11155599B2
公开(公告)日：2021-10-26
申请号：US14375842
申请日：2013-02-01
发明人： Juan Fueyo-Margareto , Candelaria Gomez-Manzano , W. K. Alfred Yung , Victor Krasnykh , Hong Jiang
IPC分类号： C12N7/00 , C07K14/705 , C07K14/47 , A61K39/00
摘要： The present invention is directed to adenoviruses for use in cancer therapy which comprise one or more heterologous nucleic acid sequences encoding a tumor antigen, whereby the adenovirus expresses the tumor antigen(s) on its surface.
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公开(公告)号：US20210301264A1
公开(公告)日：2021-09-30
申请号：US17304006
申请日：2021-06-11
发明人： Frank Tufaro , Juan Fueyo-Margareto , Candelaria Gomez-Manzano , Charles Conrad , Alfred W.K. Yung , Hong Jiang
IPC分类号： C12N7/00 , A61K35/761 , C07K14/52 , A61K31/495 , A61K38/21 , A61K45/06
摘要： Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
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公开(公告)号：US20140377294A1
公开(公告)日：2014-12-25
申请号：US14375842
申请日：2013-02-01
发明人： Juan Fueyo-Margareto , Candelaria Gomez-Manzano , W.K. Alfred Yung , Victor Krasnykh , Hong Jiang
IPC分类号： C07K14/705 , C12N7/00
CPC分类号： C07K14/70596 , A61K39/0011 , A61K2039/5256 , C07K14/4748 , C12N7/00 , C12N2710/10034 , C12N2710/10343
摘要： The present invention is directed to adenoviruses for use in cancer therapy which comprise one or more heterologous nucleic acid sequences encoding a tumor antigen, whereby the adenovirus expresses the tumor antigen(s) on its surface.
摘要翻译： 本发明涉及用于癌症治疗的腺病毒，其包含编码肿瘤抗原的一种或多种异源核酸序列，由此腺病毒在其表面上表达肿瘤抗原。
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