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公开(公告)号:US09809588B2
公开(公告)日:2017-11-07
申请号:US14791186
申请日:2015-07-02
发明人: Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号: C07D417/14 , C07D417/06 , C07D403/06 , C07D405/14 , C07D403/14 , C07D493/08 , C07D401/14 , A61K31/433 , A61K31/501 , A61K31/497 , A61K45/06 , A61K31/4439 , A61K31/454 , A61K31/4192 , A61K31/444
CPC分类号: C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号:US20160002204A1
公开(公告)日:2016-01-07
申请号:US14791284
申请日:2015-07-03
发明人: Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Christopher Lawrence Carroll , Timothy McAfoos , Wylie Palmer , Zachary Herrera
IPC分类号: C07D401/06 , A61K31/444 , A61K45/06 , A61K31/4439 , C07D401/14 , A61K31/501 , C07D403/06 , A61K31/513 , C07D417/06 , C07D487/04 , A61K31/519 , A61K31/4545 , C07D405/14 , C07D403/14 , C07D409/14 , A61K31/5377 , A61K31/541 , A61N5/10 , A61N7/00 , C07D417/14
CPC分类号: C07D401/06 , A61K31/00 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04
摘要: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号:US10766892B2
公开(公告)日:2020-09-08
申请号:US16412050
申请日:2019-05-14
发明人: Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号: C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497
摘要: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号:US11370786B2
公开(公告)日:2022-06-28
申请号:US16925974
申请日:2020-07-10
发明人: Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号: C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497
摘要: Disclosed herein are compounds of structural Formula VIIa or VIIb: or a pharmaceutically acceptable salt thereof, and compositions thereof useful in the treatment of GLS1 mediated diseases, such as cancer. Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号:US10344025B2
公开(公告)日:2019-07-09
申请号:US15624168
申请日:2017-06-15
发明人: Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号: C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497 , C07D403/06 , A61K31/501
摘要: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号:US20160009704A1
公开(公告)日:2016-01-14
申请号:US14791186
申请日:2015-07-02
发明人: Maria Emilia Di Francesco , Philip Jones , Timothy Heffernan , Matthew M. Hamilton , Zhijun Kang , Michael J. Soth , Jason P. Burke , Kang Le , Christopher Lawrence Carroll , Wylie S. Palmer , Richard Lewis , Timothy McAfoos , Barbara Czako , Gang Liu , Jay Theroff , Zachary Herrera , Anne Yau
IPC分类号: C07D417/14 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497 , A61K31/4439
CPC分类号: C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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