公开(公告)号：US20220194990A1

公开(公告)日：2022-06-23

申请号：US17310245

申请日：2020-01-31

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Jonathan Herskovitz ,  Mahmudul Hasan ,  Bhavesh Kevadiya

IPC: C07K14/005

Abstract: The present invention provides virus-like particles and methods of manufacture and use thereof. In accordance with the instant invention, virus-like particles (VLPs), particularly human immunodeficiency virus (HIV) VLPs, are provided. The HIV VLPs comprise at least one HIV structural protein and the HIV envelope protein, but lacks the HIV genome and lacks functional reverse transcriptase and integrase.

公开(公告)号：US20240165266A1

公开(公告)日：2024-05-23

申请号：US18550828

申请日：2022-03-17

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Jonathan Herskovitz ,  Mahmudul Hasan ,  Bhavesh Kevadiya ,  Milankumar Patel

IPC: A61K48/00 ,  A61K9/127 ,  A61K31/7105 ,  A61K38/46 ,  A61K51/12 ,  A61P31/18 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88

CPC classification number: A61K48/0041 ,  A61K9/1272 ,  A61K31/7105 ,  A61K38/465 ,  A61K51/1244 ,  A61P31/18 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N2310/20

Abstract: Disclosed herein are methods and compositions for lipid nanoparticles encapsulating a nucleic acid encoding for a CRISPR nucleic acid complementary to a HIV-1 gene. Also disclosed are lipid nanoparticle compositions, nucleotides, cells, and methods associated with the compositions.

公开(公告)号：US20240139310A1

公开(公告)日：2024-05-02

申请号：US18279459

申请日：2022-03-09

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. GENDELMAN ,  Bhavesh Kevadiya ,  Farah Shahjin ,  Milankumar Patel

IPC: A61K39/215 ,  A61K9/16 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61K9/1647 ,  A61K9/1682 ,  A61P31/14 ,  A61K2039/5252

Abstract: The present invention provides porous microparticles, particularly layer-by-layer microparticles, and methods of use thereof.