公开(公告)号：US11154557B2

公开(公告)日：2021-10-26

申请号：US17301030

申请日：2021-03-22

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K31/535 ,  A61K31/495 ,  A61K9/50 ,  A61K31/5365 ,  A61P31/18 ,  A61K9/00 ,  A61K9/16

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US20210275535A1

公开(公告)日：2021-09-09

申请号：US17303228

申请日：2021-05-24

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K31/5365 ,  A61P31/18 ,  A61K9/16 ,  A61K9/00

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US20180303911A1

公开(公告)日：2018-10-25

申请号：US16021537

申请日：2018-06-28

Applicant: Board of Regents of the University of Nebraska

Inventor： Alexander Kabanov ,  Tatiana Bronich ,  Elena Batrakova ,  Howard Gendelman

IPC: A61K38/44 ,  A61K38/46

CPC classification number: A61K38/44 ,  A61K38/446 ,  A61K38/465

Abstract: Compositions and methods for the delivery of a protein of interest are provided.

公开(公告)号：US20230122226A1

公开(公告)日：2023-04-20

申请号：US17905407

申请日：2021-03-05

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Jonathan Herskovitz ,  Mahmudul Hasan

IPC: C12N9/22 ,  C12N15/86 ,  A61P31/18

Abstract: Nucleic acids for use in CRISPR systems for treating HIV infections are disclosed. Pharmaceutical compositions incorporating the nucleic acids are disclosed as are methods of treating HIV using the nucleic acids.

公开(公告)号：US20240123034A1

公开(公告)日：2024-04-18

申请号：US17768514

申请日：2020-10-15

Applicant: ModernaTX, Inc. ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Eric Yi-Chun Huang ,  Jared Iacovelli ,  Seymour De Picciotto ,  Sze-Wah Tse ,  Laurie Kenney ,  Katherine Olson ,  Howard Gendelman ,  Lee R. Mosley

IPC: A61K38/19 ,  A61K9/51 ,  A61K31/7115 ,  A61P25/16

CPC classification number: A61K38/193 ,  A61K9/5123 ,  A61K31/7115 ,  A61P25/16

Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.

公开(公告)号：US20220175936A1

公开(公告)日：2022-06-09

申请号：US17309435

申请日：2019-11-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K47/55 ,  A61P31/18 ,  A61K9/14

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US11311547B2

公开(公告)日：2022-04-26

申请号：US17303229

申请日：2021-05-24

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K31/495 ,  A61K31/505 ,  A61K9/14 ,  A61K31/5365 ,  A61P31/18 ,  A61K9/00 ,  A61K9/16 ,  A61K31/519

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US11166957B2

公开(公告)日：2021-11-09

申请号：US17303228

申请日：2021-05-24

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K31/505 ,  A61K31/5365 ,  A61P31/18 ,  A61K9/00 ,  A61K9/16 ,  A61K31/519

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US12168013B2

公开(公告)日：2024-12-17

申请号：US17655483

申请日：2022-03-18

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K31/5365 ,  A61K9/00 ,  A61K9/16 ,  A61K31/519 ,  A61P31/18

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US20220288037A1

公开(公告)日：2022-09-15

申请号：US17631955

申请日：2020-08-21

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Benson Edagwa ,  Howard Gendelman

IPC: A61K31/426 ,  A61P31/12 ,  A61K31/675

Abstract: The present invention provides prodrugs and methods of use thereof.