公开(公告)号：US20240183787A1

公开(公告)日：2024-06-06

申请号：US18411378

申请日：2024-01-12

申请人： Board of Trustees of Michigan State University

发明人： Harvey LEE ,  Connor GRADY ,  Assaf GILAD

IPC分类号： G01N21/77 ,  C07K14/00 ,  G01N31/22 ,  G01N33/24

CPC分类号： G01N21/77 ,  C07K14/00 ,  G01N31/22 ,  G01N33/24 ,  C07K2319/60 ,  G01N2021/7786

摘要： Disclosed herein are fusion peptides comprising a fluorescent domain and a rare earth element detection domain capable of binding to a rare earth element and fluorescing when exposed to light when a rare earth element is bound and compositions thereof. The fusion peptide may further comprise a leader domain and a tail domain. The fusion peptide acts as a biosensor to detect and quantify rare earth elements. Methods for imaging internal body structures, detecting rare earth elements in a biosample or environmental sample, and cleaning an environmental site are also presented.